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BACKGROUND Systemic agents in cancer treatment were often associated with possible infusion reactions (IRs). This study estimated the incidence of IRs requiring medical intervention and assessed the clinical and economic impacts of IRs in patients with colorectal cancer (CRC) treated with cetuximab. PATIENTS AND METHODS Details on patients with CRC(More)
The research results presented in this paper were obtained as part of the joint CSIRO-NASA Ageless Aerospace Vehicle (AAV) project. We describe the underlying principles, methodology, and preliminary results of modelling and simulating a multi-cellular sensor and communication network in a dynamic decentralised setting, motivated by a self-monitoring,(More)
We consider a hierarchical multicellular sensing and communication network, embedded in an ageless aerospace vehicle that is expected to detect and react to multiple impacts and damage over a wide range of impact energies. In particular, we investigate self-organization of impact boundaries enclosing critically damaged areas, and impact networks connecting(More)
In this paper we describe novel metrics measuring complexity in self-organising networks. The metrics are investigated within the context of decentralised inspections, developed and implemented as part of the joint CSIRO-NASA Ageless Aerospace Vehicle (AAV) research project. The AAV Concept Demonstrator is a hardware multi-cellular sensing and communication(More)
Self-monitoring, self-repairing aerospace vehicles require modular, flexible and adaptive sensing and communication networks. In general, a modular (multi-cellular) sensing and communication network is expected to detect and react to impact location, energy and damage over a wide range of impacts. It is critical that global response emerges as a result of(More)
A Decentralised Adaptive Clustering (DAC) algorithm for self-monitoring impact sensing networks is presented within the context of CSIRO-NASA Ageless Aerospace Vehicle project. DAC algorithm is contrasted with a Fixed-order Centralised Adap-tive Clustering (FCAC) algorithm, developed to evaluate the comparative performance. A number of simulation(More)
Efficient hierarchical architectures for reconfigurable and adaptive multi-agent networks require dynamic cluster formation among the set of nodes (agents). In the absence of centralised controllers, this process can be described as self-organisation of dynamic hierarchies, with multiple cluster-heads emerging as a result of inter-agent communications.(More)