OBJECTIVES How a randomized controlled trial (RCT) is explained to patients is a key determinant of recruitment to that trial. This study developed and implemented a simple six-step model to fully inform patients and to support them in deciding whether to take part or not. STUDY DESIGN AND SETTING Ninety-two consultations with 60 new patients were… (More)
Pragmatic multi-centre RCTs are acknowledged to be the best design for evaluating the effectiveness of health care interventions as they provide robust evidence of effect, but they often encounter recruitment difficulties. Randomised Controlled Trials (RCTs) in surgery require patients to accept uncertainty or equipoise between surgical and non-surgical… (More)
In this paper we prove a generalization of the iterated homoge-nization theorem for monotone operators, proved by Lions et al. in  and . Our results enable us to homogenize more realistic models of multiscale structures.