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Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2) < 0.2) strongly associated with CAD at a 5% false discovery(More)
It has previously been thought that there was a steep Cretaceous and Cenozoic radiation of marine invertebrates. This pattern can be replicated with a new data set of fossil occurrences representing 3.5 million specimens, but only when older analytical protocols are used. Moreover, analyses that employ sampling standardization and more robust counting(More)
We have investigated the role of myosin in cytokinesis in Dictyostelium cells by examining cells under both adhesive and nonadhesive conditions. On an adhesive surface, both wild-type and myosin-null cells undergo the normal processes of mitotic rounding, cell elongation, polar ruffling, furrow ingression, and separation of daughter cells. When cells are(More)
Molecular recognition between biotinylated bovine serum albumin and polyclonal, biotin-directed IG antibodies has been measured directly under various buffer conditions using an atomic force microscope (AFM). It was found that even highly structured molecules such as IgG antibodies preserve their specific affinity to their antigens when probed with an AFM(More)
  • P J Wagner
  • Evolution; international journal of organic…
  • 2000
Frequencies of new character state derivations are analyzed for 56 fossil taxa. The hypothesis that new character states are added continuously throughout clade history can be rejected for 48 of these clades. Two alternative explanations are considered: finite states and ordered states. The former hypothesizes a limited number of states available to each(More)
This paper presents an automatic approach for learning semantic criteria for the mass versus count noun distinction by induction over the lexical mappings contained in the Cyc knowledge base. This produces accurate results (89.5%) using a decision tree that only incorporates semantic features (i.e., Cyc ontological types). Comparable results (86.9%) are(More)
Global diversity curves reflect more than just the number of taxa that have existed through time: they also mirror variation in the nature of the fossil record and the way the record is reported. These sampling effects are best quantified by assembling and analyzing large numbers of locality-specific biotic inventories. Here, we introduce a new database of(More)
Kai Nagel,* Dietrich E. Wolf, Peter Wagner, and Patrice Simon Los Alamos National Laboratory, TSA-DO/SA Mail Stop M997, Los Alamos, New Mexico 87545 Theoretische Physik, Gerhard-Mercator-Universität, 47048 Duisburg, Germany Zentrum für Paralleles Rechnen, Universität zu Köln, 50923 Köln, Germany Deutsches Zentrum für Luftund Raumfahrt, Linder Höhe, 51170(More)
Likelihood analyses of 1176 fossil assemblages of marine organisms from Phanerozoic (i.e., Cambrian to Recent) assemblages indicate a shift in typical relative-abundance distributions after the Paleozoic. Ecological theory associated with these abundance distributions implies that complex ecosystems are far more common among Meso-Cenozoic assemblages than(More)