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Translocase of IM (inner membrane; Tim)9 and Tim10 are essential homologue proteins of the mitochondrial intermembrane space (IMS) and form a stable hexameric Tim9-Tim10 complex there. Redox-switch of the four conserved cysteine residues plays a key role during the biogenesis of these proteins and, in turn, the Tim proteins play a vital chaperone-like role(More)
BACKGROUND Natural killer (NK) cells can induce death in cancer cells. Previous studies suggest that lidocaine may decrease the function of NK cells. However, it is unknown whether lower concentrations of lidocaine, usually found in patients managed with continuous infusions, also impair the function of NK cells. We hypothesized that lidocaine at low(More)
An electrical and physical design power optimization methodology and design techniques developed to create an ARM 1136SF-S microprocessor in 9Onm standard CMOS are presented. A 40% reduction in power dissipation has been achieved while maintaining a 355 MHz operating clock rate under typical conditions. Functional and electrical design requirements were(More)
A system-centric, fully-hierarchical design methodology and design techniques developed to create four ICs, which provide the core functionality of a multi-gigabit switching network system, are presented. The system is capable of switching more than 500 million packets per second. Electrical and physical design methods for one IC are described. /spl sim/76M(More)
NASA Ames, in conjunction with the Johnson Space Center (JSC), is building a platform to enable mission control operations software to be assembled from flexible collections of components and services. MCT is designed to support rapid creation, composition, visualization, and certification of user objects, while using social media techniques to help(More)
A system-centric, fully-hierarchical design methodology and design techniques developed to create four ICs, which provide the core functionality of a multi-Gigabit switching network system, are presented. The system is capable of switching more than 500 million packets per second. Electrical and physical design methods for one IC are described. /spl sim/76(More)
Contents of the IAnewsletter are not necessarily the official views of or endorsed by the U.S. Government, DoD, or DDR&E. The mention of commercial products and/or services does not imply endorsement by the DoD or DDR&E. Inquiries about IATAC capabilities, products, and services may be addressed to— To submit your articles, notices, programs, or ideas for(More)
A new approach to testing is described that combines extreme programming with model-based testing. In extreme programming (XP) [1], testing plays a special role. Development is incremental and at each stage the current set of tests forms a kind of specification. It is also recommended that tests be automated, and several testing frameworks have been(More)
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