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  • Heidi R Kast, Bryan Goodwin, +7 authors Peter A. Edwards
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2002 (First Publication: 25 January 2002)
  • The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the apical membrane of the hepatocyte into the bile canaliculi. We identifiedContinue Reading
  • Amudhan Venkateswaran, Bryan A. Laffitte, +4 authors Peter Tontonoz
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2000 (First Publication: 24 October 2000)
  • LXR alpha is a nuclear receptor that has previously been shown to regulate the metabolic conversion of cholesterol to bile acids. Here we define a role for this transcription factor in the control ofContinue Reading
  • Sean B. Joseph, Bryan A. Laffitte, +6 authors Peter Tontonoz
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2002 (First Publication: 29 March 2002)
  • The nuclear receptors LXRα and LXRβ have been implicated in the control of lipogenesis and cholesterol homeostasis. Ligand activation of these receptors in vivoinduces expression of the LXR targetContinue Reading