Peter Smetana

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A new method is proposed to evaluate the dynamics of QT interval adaptation in response to heart rate (HR) changes. The method considers weighted averages of RR intervals (RR) preceding each cardiac beat to express RR interval history accounting for the influence on repolarization duration. A global optimization algorithm is used to determine the weight(More)
The reason for sex differences in arrhythmic risk remains unclear. Heterogeneity of ventricular repolarization is directly linked to arrhythmogenesis; thus we investigated repolarization homogeneity and its circadian pattern in men and women. During 24-h Holter recordings in 60 healthy subjects (27 males), a 12-lead electrocardiogram (ECG) was obtained(More)
Differences in action potential duration reflect differences in ion channel properties. These properties also determine rate dependence of action potential duration, and transmural dispersion was confirmed experimentally to increase with cycle length. While several electrocardiographic indexes characterizing repolarization abnormalities have been proposed,(More)
Differences in APD reflect differences in ion channel properties. These properties also determine rate dependence of APD and transmural dispersion was confirmed experimentally to increase with cycle length. While several electrocardiographic indices characterising repolarisation abnormalities have been proposed, studies of their heart rate dependence are(More)
The review summarises the present knowledge on the sex differences in cardiac autonomic regulations and in related aspects of electrocardiography with particular attention to myocardial repolarisation. Although some of the sex differences are far from fully established, multitude of observations show consistent differences between women and men. Despite(More)
Heart rate turbulence (HRT) is a measure of the autonomic response to perturbations of arterial blood pressure after single ven-tricular premature complex (VPC). This response consists of a short initial acceleration followed by a gradual deceleration of the heart rate 1. One of the mechanisms proposed for the genesis of HRT is the alteration in the(More)
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