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BACKGROUND An elevated risk of lung cancer among workers in chromate production facilities has previously been reported. This excess risk is believed to be the result of exposure to hexavalent chromium. There have been mixed reports about whether trivalent chromium exposure is also associated with an excess lung cancer risk. Previous studies of measured(More)
Relatively few investigators have estimated quantitative exposure levels in epidemiologic studies, and, for those that have, few have discussed the strengths and weakness of their estimation method with respect to other methods. This paper reviews the steps for developing quantitative exposure estimates that have been used in published studies. First, the(More)
Adverse effects of antineoplastic drug exposure have been well documented in therapeutically treated patients and proposed as a potential hazard for occupationally exposed populations. Concern stems from accrued evidence of mutagenicity, carcinogenicity, and teratogenicity of many of these drugs. While the clinical significance of occupational exposure is(More)
OBJECTIVES To evaluate associations between cumulative and peak formaldehyde exposure and mortality from acute myeloid leukemia (AML) and other lymphohematopoietic malignancies. METHODS Cox proportional hazards analyses. RESULTS Acute myeloid leukemia was unrelated to cumulative exposure. Hodgkin lymphoma relative risk estimates in the highest exposure(More)
Traditional industrial hygiene assessment of exposure to polychlorinated biphenyls (PCBs) has long focused on air concentrations as a surrogate measure of worker dose. Evidence is presented to support the hypothesis that the dermal and dermal/oral routes of worker PCB exposure are major contributors to total PCB body burden in the group of transformer(More)
Potential exposures to extremely low frequency (ELF) magnetic fields were investigated in response to worker concerns about an apparent increased spontaneous abortion risk in a payroll office environment. Concern in this office centered on the use of video display terminals (VDTs), which have been investigated as a potential cause of adverse reproductive(More)
This case-control study evaluated the relation between potential exposure to chemical and physical agents and the occurrence of intracranial tumors among employees at a petrochemical research facility. Cases were employees with glioma (n = 6) or benign intracranial tumors (n = 6). Controls (n = 119) were individually matched to cases on gender and birth(More)
BACKGROUND From 1970 through 1997, 17 intracranial neoplasms were identified among 6,800 employees of a petrochemical research facility. This investigation describes the case-series. METHODS The intracranial neoplasms were identified by self reports and record linkages, and were confirmed by medical records and a pathology review. Standardized incidence(More)
Carpeting is one of the most common and perhaps the most important reservoir of aeroallergens and other components of dust found in residential or commercial settings. This research evaluated factors that affect the retention of dust mite allergens on different types of tufted carpet commonly found in homes and offices. Twenty-six types of carpet were(More)