Peter S Stewart

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This study determined the influence of mixing speed and time on the dissolution and deagglomeration of a micronised, poorly water-soluble drug, indomethacin, in lactose interactive mixtures. Mixing occurred in a Turbula mixer; dissolution studies were performed using the USP paddle method, and the extent of deagglomeration was determined using modelling(More)
An electron microscopic study of a lipoprotein fraction isolated by ultracentrifugation from skim milk has shown that it is composed of membrane. It is believed that the majority of this membrane arises from shed microvilli. The microvilli may be derived from excess Golgi membrane which accumulates as plasma membrane during the secretion of milk proteins(More)
Brain tissue swelling is a dangerous consequence of traumatic injury and is associated with raised intracranial pressure and restricted blood flow. We consider the mechanical effects that drive swelling of brain tissue slices in an ionic solution bath, motivated by recent experimental results that showed that the volume change of tissue slices depends on(More)
PETER S. STEWART, MATTHIAS HEIL, SARAH L. WATERS AND OLIVER E. JENSEN† Department of Engineering Sciences and Applied Mathematics, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA School of Mathematics, University of Manchester, Oxford Road, Manchester M13 9PL, UK Oxford Centre for Industrial and Applied Mathematics, University of(More)
Recent reports that macroscopic vortex flows can discriminate between chiral molecules or their assemblies sparked considerable scientific interest both for their implications to separations technologies and for their relevance to the origins of biological homochirality. However, these earlier results are inconclusive due to questions arising from(More)
Membrane fouling during particle filtration occurs through a variety of mechanisms, including internal pore clogging by contaminants, coverage of pore entrances, and deposition on the membrane surface. Each of these fouling mechanisms results in a decline in the observed flow rate over time, and the decrease in filtration efficiency can be characterized by(More)
PURPOSE There is no easy way to estimate the intracranial pressure (ICP) noninvasively. The retinal vein can exhibit large amplitude oscillations at the level of the lamina cribrosa under certain circumstances. The aims of this study were to develop a theoretical understanding of the conditions required to establish this vigorous oscillatory behavior and to(More)
The failure of neodymium-doped yttrium aluminium garnet (Nd:YAG) peripheral iridotomy (PI) to prevent and relieve primary acute angle-closure glaucoma (AACG) has been well documented in the literature and has been attributed to an inadequate size of PI. In cases of uveitis and iris bombe-associated AACG the failure rate is significantly greater, in the(More)
Chemical oscillations are studied using a continuous-flow microfluidic system transforming the time domain of chemical oscillators into a spatial domain. This system allows one (i) to monitor the dynamics of chemical oscillators with the accuracy of vigorously stirred batch reactors but with the ease and speed of CSTRs and (ii) to rapidly screen the phase(More)