Peter S. Randolph

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Hfq and other Sm proteins are central in RNA metabolism, forming an evolutionarily conserved family that plays key roles in RNA processing in organisms ranging from archaea to bacteria to human. Sm-based cellular pathways vary in scope from eukaryotic mRNA splicing to bacterial quorum sensing, with at least one step in each of these pathways being mediated(More)
A history of the Sm/Lsm-SmAP-Hfq family. Human Sm proteins were discovered over 30 y ago as a group of small antigens involved in the autoimmune disease systemic lupus erythematosus. The ≈80-residue proteins were identified in association with ribonucleoprotein (RNP) complexes from eukaryotic cellular extracts. Other early work uncovered vital roles for Sm(More)
The host factor Hfq, as the bacterial branch of the Sm family, is an RNA-binding protein involved in the post-transcriptional regulation of mRNA expression and turnover. Hfq facilitates pairing between small regulatory RNAs (sRNAs) and their corresponding mRNA targets by binding both RNAs and bringing them into close proximity. Hfq homologs self-assemble(More)
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