Peter Südbeck

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Haploinsufficiency for SOX9 has recently been identified as the cause for both campomelic dysplasia (CD), a human skeletal malformation syndrome, and the associated autosomal XY sex reversal1,2. SOX9 contains a putative DNA-binding motif known as the high-mobility group (HMG) domain characterizing a whole class of transcription factors3. We show in cell(More)
It has previously been shown that, in the heterozygous state, mutations in the SOX9 gene cause campomelic dysplasia (CD) and the often associated autosomal XY sex reversal. In 12 CD patients, 10 novel mutations and one recurrent mutation were characterized in one SOX9 allele each, and in one case, no mutation was found. Four missense mutations are all(More)
The SOX genes form a gene family related by homology to the high-mobility group (HMG) box region of the testis-determining gene SRY. We have cloned and sequenced the SOX10 and Sox10 genes from human and mouse, respectively. Both genes encode proteins of 466 amino acids with 98% sequence identity. Significant expression of the 2.9-kb human SOX10 mRNA is(More)
Sex determination in mammals is controlled by various transcription factors. Following the identification of SRY on the Y chromosome, several other factors have been identified. They can normally be identified as being involved in sex determination by the identification of sex reversal mutations or deletions, functional studies, and also by male-specific(More)
SRY and SOX9, members of the family of high-mobility group (HMG) domain transcription factors, are both essential for testis formation during human embryonic development. The HMG domain is a DNA-binding and DNA-bending motif comprising about 80 amino acid residues. It has been shown that SRY and SOX9 are nuclear proteins. Using normal or mutant(More)
In 1991 a second female Grey-headed WoodpeckerPicus canus rearing the young was recorded. This seems to be the first case of helping recorded in European woodpeckers so far. The conditions and advantages of helping and being helped are described with regard to the special situation of an isolated population in the north-west of Lower Saxony, Germany.(More)
350000–400000 pairs of breeding birds as well as 10–12 millions of migratory waterbirds use the Danish-German-Dutch Wadden Sea as a feeding, roosting and moulting area. The exact number of migrating birds using the Wadden Sea is unknown. 4 Wadden Sea breeding bird species are (probably) extinct in the area, e.g. Caspian Tern (Sterna caspia) and Roseate Tern(More)
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