Peter Rose

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This paper presents a case of discrete thalamic infarction which damaged various structures in the region of the left thalamus. Localisation of the lesion was confirmed by MRI scanning. From the localisation of the lesion it was concluded that damage has been inflicted on the hippocampal pathway, the amygdalar pathway, and the pathway from perirhinal cortex(More)
BACKGROUND Colorectal cancer can present in a variety of ways, and with any of several symptoms. Different referral routes from primary to secondary care cater for these different presentations. The route that has received most investment in the UK National Health Service is the 2-week clinic, but the proportions of patients taking this and other routes to(More)
BACKGROUND There is increased pressure on primary care physicians to monitor oral anticoagulation. OBJECTIVE To test the null hypothesis that oral anticoagulation care can be provided at least as well in primary care through a nurse-led clinic, involving near-patient testing and computerized decision support software, compared with routine hospital(More)
BACKGROUND Recommendations given for intravenous iron treatment are typically not supported by a high level of evidence. This meta-analysis addressed this by summarising the available date from clinical trials of ferric carboxymaltose using clinical trial reports and published reports. METHODS Clinical trial reports were supplemented by electronic(More)
Dabigatran is an oral direct thrombin inhibitor (DTI) licensed for stroke prevention in atrial fibrillation and likely to be soon approved in Europe for treatment of venous thrombosis. Predictable pharmacokinetics and a reduced risk of intracranial haemorrhage do not negate the potential risk of haemorrhage. Unlike warfarin, there is no reversal agent and(More)
Addition of a cholinergic agonist carbachol and vasoactive intestinal peptide (VIP) to dispersed rat exorbital lacrimal gland acini produces protein secretion, measured by secretion of the enzyme peroxidase, that was statistically significantly greater than additive (potentiated). To determine where in stimulus-secretion coupling these secretagogues(More)
INTRODUCTION Limb salvage with endoprosthetic reconstruction is the standard of care for the management of lower-extremity bone tumours in skeletally mature patients. The risk of deep postoperative infection in these procedures is high and the outcomes can be devastating. The most effective prophylactic antibiotic regimen remains unknown, and current(More)
Factor VIII related activities and factor VIII related antigen multimeric analysis have been assessed in two sporadic and eleven epidemic cases of haemolytic uraemic syndrome. In all patients factor VIII related antigen was raised and had an abnormal multimer pattern at presentation. The return to normal of factor VIII related antigen values and multimeric(More)
Certain strains of Escherichia coli producing verotoxin have been isolated in the stools of patients with the haemolytic uraemic syndrome. A platelet aggregating activity has been found in normal plasma after incubation with verotoxin at 37 degrees C for 24 h. This activity, unlike neuraminidase, has an effect that is independent of changing factor VIII(More)
Two meningiomas were investigated that consisted largely of myxoid tissue. Staining with Alcian blue and incubation with staphylococcal, Streptomyces or testicular hyaluronidase revealed that the matrix of the myxoid tissue contained hyaluronic acid and chondroitin sulphate. Special fixation was used for ultrastructural preservation of the myxoid matrix,(More)