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A hallmark of chronic heart failure (CHF) is an increased sympathetic tone resulting in autonomic imbalance. Renal denervation (DNx) in CHF patients has resulted in symptomatic improvement, but the protective mechanisms remain unclear. We hypothesized in CHF, unilateral renal DNx would improve cardiac autonomic balance. The present study used conscious,(More)
TO THE EDITOR: We read with great interest the recent work by Martelli et al. (6), published in American Journal of Physiology Heart and Circulatory Physiology, that describes experiments in conscious sheep in which cardiac sympathetic nerve activity (CSNA), heart rate variability (HRV), and baroreflex sensitivity (BRS) were measured. CSNA did not correlate(More)
The function of the renal nerves has been an area of scientific and medical interest for many years. The recent advent of a minimally invasive catheter-based method of renal denervation has renewed excitement in understanding the afferent and efferent actions of the renal nerves in multiple diseases. While hypertension has been the focus of much this work,(More)
Tubuloglomerular feedback and the myogenic response are widely appreciated as important regulators of renal blood flow, but the role of the sympathetic nervous system in physiological renal blood flow control remains controversial. Where classic studies using static measures of renal blood flow failed, dynamic approaches have succeeded in demonstrating(More)
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