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We studied the degree of plasma tryptophan depletion produced by giving normal human males different amounts of a tryptophan-free (T-) amino acid mixture. From the results of this and other studies we concluded that the maximum degree of tryptophan depletion can be produced by a 31.5 g mixture of seven essential amino acids. Administration of a T−amino acid(More)
Cerebellar and limbic system pathologies have been reported in persons with autism. Because these brain areas are involved centrally in the acquisition and performance in classical eye-blink conditioning, this study evaluated conditioning in 11 persons with autism. Compared to matched controls, persons with autism learned the task faster but performed(More)
Rationale: Impulsivity is associated with increased risk for alcoholism. Alcohol also may increase impulsive behavior, although little is known about the processes underlying this effect. Objectives: This study tested a model proposing that the executive processes of working memory (WM) and conditional associative learning (CAL) modulate behavioral(More)
This study involves the development and initial validation of a questionnaire measuring the propensity for sexual inhibition and excitation in men: the Sexual Inhibition Sexual Excitation Scales (SIS/SES). The underlying theoretical model postulates that sexual response and associated behavior depend on dual control mechanisms, involving excitatory and(More)
BACKGROUND Disinhibited, antisocial traits increase the risk for early-onset alcoholism. Research also suggests that decision biases which favor immediate large rewards regardless of long-term consequences may be important mechanisms associated with the biological substrates of antisocial traits. This study tested the hypothesis that early-onset alcoholism(More)
Psychophysiological reactivity to nonaversive (1-KHz, 70-db tones) and aversive stimuli (shock) was examined in nonalcoholic men with multigenerational family histories (MFH) of alcoholism and family history negative (FH-) men, while sober and after consuming alcohol. In comparison with FH- Ss, sober MFH Ss had significantly larger skin conductance (SC)(More)
OBJECTIVE Males with a family history of alcoholism (Family History Positive [FHP]) have frequently been reported to show an attenuated amplitude of the P300 component of the EEG event-related potential (ERP). The purpose of the present study was to explore the influence of incentives on the amplitude of the P300 to Target stimuli in FHP and FHN (Family(More)
This study tested the hypothesis that short-term memory (STM) capacity moderates the effect of social deviance on alcohol problems. Personality, cognitive ability, and alcohol use and abuse were assessed in the adult offspring of alcoholics (FHPs; n = 153) and the adult offspring of nonalcoholics (FHNs; n = 150). The results revealed that STM capacity(More)
The present research assessed the conditions under which subjects who consume alcohol and those who consume a placebo beverage, and who report consuming alcohol on a manipulation check question, are equivalent with respect to subjective responses to alcohol. Male subjects were told that they were drinking alcohol and consumed one of four beverages:(More)