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A straightforward and efficient synthesis of several novel pyrrole and pyrrolopyrimidine derivatives and their inhibitory effects on the catalytic activity of the IMP-1 MBL from Klebsiella pneumoniaContinue Reading
  • Omid Khalili Arjomandi, Waleed M. Hussein, +4 authors Ross P. McGeary
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2016 (First Published: 1 May 2016)
  • There are currently no clinically available inhibitors of metallo-β-lactamases (MBLs). These enzymes confer resistance to bacteria against a broad range of commonly used β-lactam antibiotics, and areContinue Reading
  • Peter P. Vella, Manfredi Miraula, +6 authors Nataša D. Mitić
  • Chemistry, Medicine
  • JBIC Journal of Biological Inorganic Chemistry
  • 2013 (First Published: 1 October 2013)
  • Metallo-β-lactamases (MBLs) are a family of metalloenzymes that are capable of hydrolyzing β-lactam antibiotics and are an important means by which bacterial pathogens use to inactivate antibiotics.Continue Reading