Peter Nightingale

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BACKGROUND We assessed whether remote ischemic preconditioning (RIPC) improves myocardial, renal, and lung protection after on-pump coronary surgery. METHODS AND RESULTS This was a single-center, prospective, randomized (1:1), placebo-controlled trial. Patients, investigators, anesthetists, surgeons, and critical care teams were blinded to group(More)
OBJECTIVES To implement and assess a rules based computerised prescribing system with the aim of improving the safety of prescriptions and the administration of drugs. DESIGN Analysis of performance of computerised system plus questionnaire survey of users. SETTING 64 bed renal unit in a teaching hospital. INTERVENTION : Introduction of the system(More)
OBJECTIVE To contrast the effect of the burden of vasculitis activity with the burden of adverse events on 1-year mortality of patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS This study assessed the outcome and adverse events in patients prospectively recruited to four European AAV clinical trials. Data on 524(More)
OBJECTIVE To observe intracranial pressure in women with idiopathic intracranial hypertension who follow a low energy diet. DESIGN Prospective cohort study. SETTING Outpatient department and the clinical research facility based at two separate hospitals within the United Kingdom. PARTICIPANTS 25 women with body mass index (BMI) >25, with active(More)
BACKGROUND Communicating information about disease-modifying anti-rheumatic drugs (DMARDs) before patients start treatment is a key role for some rheumatology clinical nurse specialists. This is done in our unit to promote understanding of the risks and benefits of drug therapy and encourage timely and reliable use of DMARDs. Information is routinely(More)
CONTEXT Adrenal tumors have a prevalence of around 2% in the general population. Adrenocortical carcinoma (ACC) is rare but accounts for 2-11% of incidentally discovered adrenal masses. Differentiating ACC from adrenocortical adenoma (ACA) represents a diagnostic challenge in patients with adrenal incidentalomas, with tumor size, imaging, and even histology(More)
CONTEXT Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, anovulation, and susceptibility to the metabolic syndrome. Altered peripheral cortisol metabolism has been reported in PCOS, but also in simple obesity. OBJECTIVE The aim of the study was to describe cortisol metabolism and metabolic characteristics of a large PCOS cohort and(More)
The aim of the present study was to identify alpha(1)-antitrypsin (alpha(1)-AT)-deficient patients who had rapidly progressive disease. PiZ patients (n = 101) underwent annual lung function measurements over a 3-yr period, and the results were related to factors that may influence decline. The mean annual decline in forced expiratory volume in 1 s (FEV(1))(More)
OBJECTIVES Early therapy improves outcomes in rheumatoid arthritis (RA). It is therefore important to improve predictive algorithms for RA in early disease. This study evaluated musculoskeletal ultrasound, a sensitive tool for the detection of synovitis and erosions, as a predictor of outcome in very early synovitis. METHODS 58 patients with clinically(More)