Peter Minette

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We have investigated whether prejunctional inhibitory muscarinic receptors ("autoreceptors") exist on cholinergic nerves in human airways in vitro and whether guinea pig trachea provides a good model for further pharmacological characterization of these receptors. Pilocarpine was used as a selective agonist and gallamine as a selective antagonist of these(More)
Several subtypes of muscarinic receptors have been identified in airways and lung parenchyma of different species, including humans. M1 receptors may be present in parasympathetic ganglia where they appear to facilitate ganglionic neurotransmission. M2 receptors seem to be located on cholinergic nerve endings where they function as "autoreceptors,"(More)
2 ACKNOWLEDGEMENTS The researchers would like to dedicate this research to the memory of Ms Seana Campbell, a very talented, hardworking and creative young researcher who enriched all people whose lives she touched, and who died too young. The researchers would also like to thank the following University of Miami and FIU Students, other student researchers,(More)
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