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AIM If appropriately accounted for in a pharmacokinetic (PK)-pharmacodynamic (PD) model, time-varying covariates can provide additional information to that obtained from time-constant covariates. The aim was to present and apply two models applicable to time-varying covariates that capture such additional information. METHODS The first model estimates(More)
The support for complex queries, such as range, prefix and aggregation queries, over structured peer-to-peer systems is currently an active and significant topic of research. This paper demonstrates how Skip Tree Graph, as a novel structure, presents an efficient solution to that problem area through provision of a distributed search tree functionality on(More)
The predictive value of longitudinal biomarker data (vascular endothelial growth factor (VEGF), soluble VEGF receptor (sVEGFR)-2, sVEGFR-3, and soluble stem cell factor receptor (sKIT)) for tumor response and survival was assessed based on data from 303 patients with imatinib-resistant gastrointestinal stromal tumors (GIST) receiving sunitinib and/or(More)
This paper describes two approaches suitable for an FPGA implementation of Walsh-Hadamard transforms. These transforms are important in many signal-processing applications including speech compression, filtering and coding. Two novel architectures for the Fast Hadamard Transforms using both systolic architecture and distributed arithmetic techniques are(More)
A modeling framework relating exposure, biomarkers (vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor (sVEGFR)-2, -3, soluble stem cell factor receptor (sKIT)), and tumor growth to overall survival (OS) was extended to include adverse effects (myelosuppression, hypertension, fatigue, and hand-foot syndrome(More)
The European Medicines Agency (EMA) and the Federation of Pharmaceutical Industries and Associations (EFPIA) hosted a workshop on modeling and simulation (M&S).(1) Representatives from industry, academia, and regulatory agencies from Europe and beyond discussed the role of M&S in the development and registration of medicinal products within plenary and(More)