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AIM If appropriately accounted for in a pharmacokinetic (PK)-pharmacodynamic (PD) model, time-varying covariates can provide additional information to that obtained from time-constant covariates. The aim was to present and apply two models applicable to time-varying covariates that capture such additional information. METHODS The first model estimates(More)
The support for complex queries, such as range, prefix and aggregation queries, over structured peer-to-peer systems is currently an active and significant topic of research. This paper demonstrates how Skip Tree Graph, as a novel structure, presents an efficient solution to that problem area through provision of a distributed search tree functionality on(More)
This paper describes two approaches suitable for an FPGA implementation of Walsh-Hadamard transforms. These transforms are important in many signal-processing applications including speech compression, filtering and coding. Two novel architectures for the Fast Hadamard Transforms using both systolic architecture and distributed arithmetic techniques are(More)
The predictive value of longitudinal biomarker data (vascular endothelial growth factor (VEGF), soluble VEGF receptor (sVEGFR)-2, sVEGFR-3, and soluble stem cell factor receptor (sKIT)) for tumor response and survival was assessed based on data from 303 patients with imatinib-resistant gastrointestinal stromal tumors (GIST) receiving sunitinib and/or(More)
A modeling framework relating exposure, biomarkers (vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor (sVEGFR)-2, -3, soluble stem cell factor receptor (sKIT)), and tumor growth to overall survival (OS) was extended to include adverse effects (myelosuppression, hypertension, fatigue, and hand-foot syndrome(More)
The European Medicines Agency (EMA) and the Federation of Pharmaceutical Industries and Associations (EFPIA) hosted a workshop on modeling and simulation (M&S).(1) Representatives from industry, academia, and regulatory agencies from Europe and beyond discussed the role of M&S in the development and registration of medicinal products within plenary and(More)