Peter Middleton

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This paper examines the efficiency and effectiveness of a prescriptive systems development methodology in practice. The UK Government's mandatory Structured Systems Analysis and Design Method (SSADM) was examined to determine its value to software projects. The evidence was collected from interviews with 17 project managers, discussions with participants on(More)
—This case study examines how the lean ideas behind the Toyota production system can be applied to software project management. It is a detailed investigation of the performance of a nine-person software development team employed by BBC Worldwide based in London. The data collected in 2009 involved direct observations of the development team, the kanban(More)
Langerhans cells (LC) and other antigen-presenting cells are believed to be critical in initiating graft versus host responses that influence the outcome of allogeneic hematopoietic stem cell transplantation. However, their fate in humans is poorly understood. We have sought to define the effect of conditioning regimes and graft versus host disease (GVHD)(More)
The properties of a new tumour cell line (NB1-G) derived from human neuroblastoma by xenografting in nude rats followed by adaptation to tissue culture are described. Studies using a panel of monoclonal antibodies demonstrate the neuro-ectodermal nature of the cells and support the diagnosis of the primary tumour as neuroblastoma. Cytogenetic studies have(More)
OBJECTIVE To discuss the role of depression in chronic lower back pain and comment on appropriate methods of screening and co-management. DATA SOURCES The current scientific literature was investigated using the online web databases CINAHL, Medline/PUBMED, Proquest, Meditext and from manual library searches. DATA EXTRACTION Databases were searched from(More)