Peter McCormick

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Long-term therapy with L-3,4-dihydroxyphenylalanine (L-DOPA), still the most effective treatment in Parkinson's disease (PD), is associated with severe motor complications such as dyskinesia. Experimental and clinical data have indicated that adenosine A2A receptor antagonists can provide symptomatic improvement by potentiating L-DOPA efficacy and(More)
Cluster computing frameworks such as Apache Hadoop and Apache Spark are commonly used to analyze large data sets. The analysis often involves running multiple, similar queries on the same data sets. This data reuse should improve query performance, but we find that these frameworks schedule query tasks independently of each other and are thus unable to(More)
  • Natasha Luquin, Salvador Sierra, Alberto J Rico, Virginia Gómez-Bautista, Elvira Roda, Lorena Conte-Perales +4 others
  • 2012
The A(2A)R has become a therapeutic target in Parkinson disease due to its functional role in the striatum, capable of modulating dopaminergic neurotransmission in the basal ganglia. No conclusive evidence, however, has been provided to demonstrate the existence of A(2A)Rs in the output nuclei of the basal ganglia: the internal segment of the globus(More)
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