Peter M. May

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Formation constants for the calcium(II), magnesium(II) and zinc(II) complexes of the orally effective iron chelator, pyridoxal isonicotinoyl hydrazone (PIH) and three analogues, pyridoxal benzoyl hydrazone (PBH), pyridoxalp-methoxybenzoyl hydrazone (PpMBH) and pyridoxalm-fluorobenzoyl hydrazone (PmFBH) have been determined by potentiometry at 25\dg C(More)
Formation constants for the calcium(II), copper(II), iron(II), magnesium(II), manganese(II) and zinc(II) complexes ofdl-NN'-dicarboxamidomethyl-NN'-dicarboxymethyl-1,2-diaminopropane (ICRF 198) and the 1,2-diamino-butane homologue (ICRF 226) have been measured potentiometrically at 37°C andI=150 mmol dm−3 [NaCl]. The constants are used in computer(More)
Estimates of the concentrations and identity of the predominant complexes of iron with the low-molecular-mass ligands in vivo are important to improve current understanding of the metabolism of this trace element. These estimates require a knowledge of the stability of the iron-citrate complexes. Previous studies on the equilibrium properties of the(More)
The ionic product of water, pK(w)=-log[H(+)][OH(-)], has been determined in aqueous solutions of sodium perchlorate over the concentration range of 1.0-8.0 M at 25 degrees C from high-precision potentiometric titrations carried out in cells with liquid junction using both glass and hydrogen electrodes. The glass electrode results are systematically lower(More)
Although the absolute concentrations of metal complexes in blood plasma are controlled by protein binding, the percentage distribution of transition metal ions amongst low molecular weight ligands is not. Thus, computer simulations which omit protein equilibria can nevertheless afford reliable information about such metals in the biofluid.
Formation constants for copper(II) and zinc(II) complexes of isonicotinoylhydrazine (isoniazid) and guanosine-5′-monophosphate have been measured potentiometrically at 37°C,I=150 mmol dm−3 [NaCl]. These constants have been used in computer models to assess the extent of complex formation by the drugin vivo. The simulations indicate that the predominant(More)
The metal complexing properties of two antihypertensive drugs, hydralazine (1-hydrazinophthalazine) and prizidilol (a hydrazinopyridazine), and some related ligands, have been studied using potentiometry, elemental analysis, spectrophotometry and computer simulation. The coordination chemistry of 1-hydrazinophthalazine and the hydrazinopyridazines is(More)
The thermodynamic database of the JESS (Joint Expert Speciation System) software package is described. It overcomes many existing problems associated with solution-chemistry databases. The system is fully interactive. Reactions can be expressed in any form. Any number of equilibrium constants, enthalpy, entropy and Gibbs-free energy values can be associated(More)