Peter M. Irving

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The results of an audit of the admission of epilepsy sufferers in a UK District General Hospital are presented. The results strongly suggest that most admissions were due to potentially mutable problems including poor compliance with medication rather than to difficult epilepsy per se. It is suggested that consistent support of these patients, for example(More)
OBJECTIVES Despite increased prescription of a gluten-free diet for gastrointestinal symptoms in individuals who do not have celiac disease, there is minimal evidence that suggests that gluten is a trigger. The aims of this study were to determine whether gluten ingestion can induce symptoms in non-celiac individuals and to examine the mechanism. METHODS(More)
BACKGROUND AND AIM Thymus-derived regulatory T cells (Tregs) mediate dominant peripheral tolerance and treat experimental colitis. Tregs can be expanded from patient blood and were safely used in recent phase 1 studies in graft versus host disease and type 1 diabetes. Treg cell therapy is also conceptually attractive for Crohn's disease (CD). However,(More)
Magnetic resonance enterography (MRE) is fast becoming the first-line radiological investigation to evaluate the small bowel in patients with Crohn's disease. It can demonstrate both mural and extramural complications. The lack of ionizing radiation, together with high-contrast resolution, multiplanar capability and cine-imaging make it an attractive(More)
BACKGROUND Thiopurines (azathioprine and mercaptopurine) remain integral to most medical strategies for maintaining remission in Crohn's disease (CD) and ulcerative colitis (UC). Indefinite use of these drugs is tempered by long-term risks. While clinical relapse is noted frequently following drug withdrawal, there are few published data on predictive(More)
BACKGROUND & AIMS Innate lymphoid cells (ILCs) are a heterogeneous group of mucosal inflammatory cells that participate in chronic intestinal inflammation. We investigated the role of interleukin 6 (IL6) in inducing activation of ILCs in mice and in human beings with chronic intestinal inflammation. METHODS ILCs were isolated from colons of Tbx21(-/-) ×(More)
Ulcerative colitis (UC) is a chronic relapsing and remitting inflammatory bowel disease, with a characteristic leukocytic infiltration of the mucosa. Immunosuppression including anti-TNF-α therapy is a mainstay of treatment for many; however, systemic immunosuppression is not universally effective and is associated with potential side effects. The(More)
The prevalence of oesophageal Crohn's disease (CD) is 0.3–2%. 1 Management is with corticosteroids, 5-aminosalicylic acids, immunomodulators or biologics as for active CD elsewhere plus acid suppression with proton pump inhibitors or H 2-receptor antagonists. 1 Strictures are additionally treated with repeated dilatations. 1 Surgery for strictures is(More)
BACKGROUND AND AIMS There are a number of gaps in our current quality of care for patients with inflammatory bowel diseases. This review proposes changes that could be made now to improve inflammatory bowel disease care. METHODS Evidence from the literature and clinical experience are presented that illustrate best practice for improving current quality(More)
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