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The ubiquitin-dependent proteolytic pathway plays a major role in selective protein degradation. Ubiquitination of proteins requires the sequential action of the ubiquitin-activating enzyme (E1),… (More)
- Marc G. Wathelet, Ching Hui Lin, Bhavin S Parekh, Laura Ronco, Peter M Howley, Tom Maniatis
- Molecular cell
- 1998
We have identified a virus-activated factor (VAF) that binds to a regulatory element shared by different virus-inducible genes. We provide evidence that VAF contains two members of the interferon… (More)
The E6 protein encoded by the oncogenic human papillomavirus types 16 and 18 is one of two viral products expressed in HPV-associated cancers. E6 is an oncoprotein which cooperates with E7 to… (More)
- Jon M. Huibregtse, Martin Scheffner, Sylvie Beaudenon, Peter M Howley
- Proceedings of the National Academy of Sciences…
- 1995
E6-AP is a 100-kDa cellular protein that interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53… (More)
The papillomavirus E2 protein tethers viral genomes to host mitotic chromosomes to ensure genome maintenance. We have identified the bromodomain protein Brd4 as a major cellular interacting partner… (More)
- Lan Huang, Elspeth R. E. Kinnucan, +4 authors Nikola P. Pavletich
- Science
- 1999
The E6AP ubiquitin-protein ligase (E3) mediates the human papillomavirus-induced degradation of the p53 tumor suppressor in cervical cancer and is mutated in Angelman syndrome, a neurological… (More)
- Shaila Rahman, Mathew E. Sowa, +4 authors Peter M Howley
- Molecular and cellular biology
- 2011
Bromodomain protein 4 (Brd4) plays critical roles in development, cancer progression, and virus-host pathogenesis. To gain mechanistic insight into the various biological functions of Brd4, we… (More)
- Nicholas Dyson, Peter M Howley, Karl Münger, E E Harlow
- Science
- 1989
Deletions or mutations of the retinoblastoma gene, RB1, are common features of many tumors and tumor cell lines. Recently, the RB1 gene product, p105-RB, has been shown to form stable protein/protein… (More)
- Jon M. Huibregtse, Martin Scheffner, Peter M Howley
- The EMBO journal
- 1991
The E6 protein of human papillomavirus types 16 and 18 (HPV-16 and HPV-18) can stably associate with the p53 protein in vitro. In the presence of rabbit reticulocyte lysate, this association leads to… (More)
- Carl C. Baker, Warner Phelps, Valerie Lindgren, Michael C Braun, M. C. Arufe Gonda, Peter M Howley
- Journal of virology
- 1987
We cloned and analyzed the integrated human papillomavirus type 16 (HPV-16) genomes that are present in the human cervical carcinoma cell lines SiHa and CaSki. The single HPV-16 genome in the SiHa… (More)