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  • Minoru Imai, Tatsuki Shiota, +17 authors Noriaki Endo
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2004 (First Publication: 1 November 2004)
  • N,N'-Disubstituted homopiperazine derivatives have been discovered as CC-chemokine receptor 2b (CCR2b) inhibitors with submicromolar activity in the CCR2b binding assay. A 4-substituted benzyl groupContinue Reading
  • Michael Joseph Luzzio, Jeffrey M. Besterman, +7 authors M Peel
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 1995 (First Publication: 1 February 1995)
  • The synthesis and antitumor activities of the novel water soluble camptothecin derivatives 7-[(4-methylpiperazino)methyl]-10,11-(methylenedioxy)-(20S)-campto thecin trifluoroacetate (6) andContinue Reading
  • Yuqiao Shen, Ying Feng, Bing Wang, Peter Leslie Myers, Daniel Chu, Leonard E. Post
  • Biology
  • 2011 (First Publication: 12 November 2011)
  • In this presentation we will present the chemical structure, biological activity and pharmacokinetic (PK) properties of BMN 673, a potent inhibitor of poly (ADP-ribose) polymerases (PARP)-1 and -2.Continue Reading
  • Wilna J. Moree, Ken-ichiro Kataoka, +15 authors Christine M. Tarby
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2004 (First Publication: 1 November 2004)
  • Structure-activity relationships (SAR) of a weakly active class of CCR2b inhibitors were utilized to initiate a lead evolution program employing the Drug Discovery Engine. Several alternativeContinue Reading