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The cyclic AMP (cAMP)-dependent catabolite repression effect in Escherichia coli is among the most intensely studied regulatory processes in biology. However, the physiological function(s) of cAMP signalling and its molecular triggers remain elusive. Here we use a quantitative physiological approach to show that cAMP signalling tightly coordinates the(More)
In many cell types, bidirectional long-range endosome transport is mediated by the opposing motor proteins dynein and kinesin-3. Here we use a fungal model system to investigate how both motors cooperate in early endosome (EE) motility. It was previously reported that Kin3, a member of the kinesin-3 family, and cytoplasmic dynein mediate bidirectional(More)
Periodic stripe patterns are ubiquitous in living organisms, yet the underlying developmental processes are complex and difficult to disentangle. We describe a synthetic genetic circuit that couples cell density and motility. This system enabled programmed Escherichia coli cells to form periodic stripes of high and low cell densities sequentially and(More)
Type IV pili (T4P) are surface structures that undergo extension/retraction oscillations to generate cell motility. In Myxococcus xanthus, T4P are unipolarly localized and undergo pole-to-pole oscillations synchronously with cellular reversals. We investigated the mechanisms underlying these oscillations. We show that several T4P proteins localize(More)
Synchronization and wave formation in one-dimensional ciliary arrays are studied analytically and numerically. We develop a simple model for ciliary motion that is complex enough to describe well the behavior of beating cilia but simple enough to study collective effects analytically. Beating cilia are described as phase oscillators moving on circular(More)
Ion channels of excitable membranes are known to be sensitive to various kinds of stimuli, but the case of simultaneous occurrence of different stimuli is poorly understood. Here, we theoretically analyze the influence of membrane tension on the dynamics of voltage-gated ion channels of excitable membranes. To do so, we develop a modification of the(More)
of dissociated molecules (and thus of the protonic carriers) increase exponentially across the molecular-ionic cross-over. In the ionic regime all the protons contribute equally to the conductivity, and a further increase in pressure increases the proton mobility without changing the number of carriers. Moving deeper into the planet, the ice core boundary(More)
Oscillations pervade biological systems at all scales. In bacteria, oscillations control fundamental processes, including gene expression, cell cycle progression, cell division, DNA segregation and cell polarity. Oscillations are generated by biochemical oscillators that incorporate the periodic variation in a parameter over time to generate an oscillatory(More)
Cooperative interactions are essential to the operation of many biochemical networks. Such networks then respond ultrasensitively in a nonlinear manner to linear changes in network input, and network output, for example, levels of a phosphorylated protein or of gene expression, becomes a sigmoidal function of concentrations of input molecules. We present a(More)
The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) correlates with poor prognosis. The ABC subtype of DLBCL is associated with constitutive activation of the NF-κB pathway, and oncogenic lesions have been identified in its regulators, including CARD11/CARMA1 (caspase recruitment domain-containing protein 11), A20/TNFAIP3, and(More)