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Loss of energy supply to neurons during stroke induces a rapid loss of membrane potential that is called the anoxic depolarization. Anoxic depolarizations result in tremendous physiological stress on the neurons because of the dysregulation of ionic fluxes and the loss of ATP to drive ion pumps that maintain electrochemical gradients. In this review, we(More)
Anoxic depolarization of pyramidal neurons results from a large inward current that is activated, in part, by excessive glutamate release during exposure to anoxia/ischemia. Pannexin-1 (Panx1) channels can be activated both by ischemia and NMDA receptors (NMDARs), but the mechanisms of Panx1 activation are unknown. We used whole-cell recordings to show that(More)
Epiplexus cells represent a population of innate immune cells on the surface of the choroid plexus (CP) in the brain ventricles. I hypothesized that the epiplexus cells are involved in immune responses of the CP via sensitivity to immune mediators such as ATP. A novel technique for the isolation of live and intact rat CP was developed that allowed, for the(More)
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