Peter L. Perrotta

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Human platelets are anucleate blood cells that retain cytoplasmic mRNA and maintain functionally intact protein translational capabilities. We have adapted complementary techniques of microarray and serial analysis of gene expression (SAGE) for genetic profiling of highly purified human blood platelets. Microarray analysis using the Affymetrix HG-U95Av2(More)
Measurement of small changes in platelet activation state (PAS) in circulating stenotic systems in vitro has been problematic because of a paucity of real-time assay methods and circulation systems of low platelet-activating potential. PAS was measured by a modified prothrombinase assay in which activated platelets provide the essential cofactors in the(More)
Platelets play critical roles in diverse hemostatic and pathologic disorders and are broadly implicated in various biological processes that include inflammation, wound healing, and thrombosis. Recent progress in high-throughput mRNA and protein profiling techniques has advanced our understanding of the biological functions of platelets. Platelet proteomics(More)
Human platelets are anucleate blood cells that retain cytoplasmic mRNA and maintain functionally intact protein transla-tional capabilities. We have adapted complementary techniques of microarray and serial analysis of gene expression (SAGE) for genetic profiling of highly purified human blood platelets. Microar-ray analysis using the Affymetrix HG-U95Av2(More)
Infusion of hematopoietic progenitor cells following high-dose chemotherapy is frequently used to treat patients with hematological malignancies and solid tumors. We have developed a comprehensive software system to monitor these patients once they are entered into an experimental protocol. The captured data encompasses all phases of progenitor cell therapy(More)
OBJECTIVE To measure free phenytoin (FP) concentrations in filtered specimens using the Abbott ARCHITECT iPhenytoin assay and to compare results from this method with results from the Abbott TDx/FLx assays. METHODS We verified accuracy, analytic measurement range, and precision for FP measurements. For correlation and therapeutic interval studies, we used(More)
Information about subscriptions and ASH membership may be found online at:. ABSTRACT Platelets play critical roles in diverse hemostatic and pathologic disorders, and are broadly implicated in various biological processes that include inflammation, wound healing and thrombosis. Recent progress in high-throughput mRNA and protein profiling techniques has(More)
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