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Azithromycin for treatment of Mycobacterium avium-intracellulare complex infection in patients with AIDS
Mycobacterium avium complex infection is common in patients with AIDS. Experimentally infected mice have been treated successfully with azithromycin, a macrolide antibiotic. We report an uncontrolledExpand
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The Efficiency of the Translocation of Mycobacterium tuberculosis across a Bilayer of Epithelial and Endothelial Cells as a Model of the Alveolar Wall Is a Consequence of Transport within Mononuclear
ABSTRACT The mechanism(s) by which Mycobacterium tuberculosis crosses the alveolar wall to establish infection in the lung is not well known. In an attempt to better understand the mechanism ofExpand
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Mycobacterium avium Invades the Intestinal Mucosa Primarily by Interacting with Enterocytes
ABSTRACT Previous studies have demonstrated that Mycobacterium avium can invade intestinal epithelial cells both in vitro and in vivo. When given to mice orally, M. aviumpreferentially interacts withExpand
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Thiosemicarbazole (Thiacetazone-Like) Compound with Activity against Mycobacterium avium in Mice
ABSTRACT In vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2Expand
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Activity of Moxifloxacin by Itself and in Combination with Ethambutol, Rifabutin, and Azithromycin In Vitro and In Vivo against Mycobacterium avium
ABSTRACT Moxifloxacin activity against Mycobacterium aviumcomplex (MAC) was evaluated in vitro against 25 strains. The MIC was determined to range from 0.125 to 2.0 μg/ml. In addition, U937Expand
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Invasion of the Brain and Chronic Central Nervous System Infection after Systemic Mycobacterium avium Complex Infection in Mice
ABSTRACT Central nervous system (CNS) infections caused by nontuberculous mycobacteria have been described previously, especially in patients with AIDS. To investigate specific aspects of theExpand
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Emergence of Mycobacterium avium Populations Resistant to Macrolides during Experimental Chemotherapy
ABSTRACT Macrolide resistance is an emerging problem in AIDS patients who receive these agents for treatment or prophylaxis againstMycobacterium avium (MAC) infection. We compared the emergence ofExpand
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Telithromycin Is Active against Mycobacterium avium in Mice despite Lacking Significant Activity in Standard In Vitro and Macrophage Assays and Is Associated with Low Frequency of Resistance during
ABSTRACT The activity of telithromycin, a new ketolide, was evaluated in vitro and in vivo against Mycobacterium avium complex (MAC) strains. The MIC of telithromycin for several M. aviumisolatesExpand
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Treatment of experimental disseminated Mycobacterium avium complex infection in mice with recombinant IL-2 and tumor necrosis factor.
Mycobacterium avium complex (MAC) is the most common bloodstream pathogen isolated from patients with AIDS. We have previously shown that TNF alone or in combination with IL-2 can activate human andExpand
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Natural Killer Cell Activity and Macrophage‐Dependent Inhibition of Growth or Killing of Mycobacterium avium Complex in a Mouse Model
Natural killer (NK) cells from spleens of normal and Mycobacterium avium complex (MAC)‐infected C57 black mice (C57 BL/6 bg/+) were examined for their capacity to activate splenic and peritonealExpand
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