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We study the condition, on a connected and locally connected geometric morphism p : E → S, that the canonical natural transformation p * → p ! should be (pointwise) epimorphic — a condition which F.W. Lawvere [11] called the 'Nullstellen-satz', but which we prefer to call 'punctual local connectedness'. We show that this condition implies that p ! preserves(More)
The identification of radioprotectors is an important goal for those involved in radiation oncology and for those interested in the investigation of the mechanisms of radiation cytotoxicity. Recently, a new class of in vitro and in vivo radioprotectors, the nitroxides, has been discovered. The nitroxides are low-molecular-weight stable free radicals which(More)
Image-guided radiation therapy delivery may be used to assess the position of the tumor and anatomical structures within the body as opposed to relying on external marks. The purpose of this manuscript is to evaluate the performance of the image registration software for automatically detecting and repositioning a 3D offset of a phantom using a kilovoltage(More)
Each full reeective subcategory X of a nitely-complete category C gives rise to a factorization system (E; M) on C, where E consists of the morphisms of C inverted by the reeexion I : C ! X. Under a simplifying assumption which is satissed in many practical examples, a morphism f : A ! B lies in M precisely when it is the pullback along the unit B : B ! IB(More)
In the literature there are several kinds of concrete and abstract cell complexes representing composition in n-categories, ω-categories or ∞-categories, and the slightly more general partial ω-categories. Some examples are parity complexes, pasting schemes and directed complexes. In this paper we give an axiomatic treatment: that is to say, we study the(More)
Preframes (directed complete posets with finite meets that distribute over the directed joins) are the algebras for an infinitary essentially algebraic theory, and can be presented by generators and relations. This result is combined with a general argument concerning categories of commutative monoids to give a very short proof of the localic Tychonoff(More)
Human bone stromal cells, after three-dimensional coculture with human prostate cancer (PCa) cells in vitro, underwent permanent cytogenetic and gene expression changes with reactive oxygen species serving as mediators. The evolved stromal cells are highly inductive of human PCa growth in mice, and expressed increased levels of extracellular matrix(More)
MOTIVATION Microarray experiments with thousands of genes on a slide and multiple slides used in any experimental set represent a large body of data with many sources of variation. The identification of such sources of variation within microarray experimental sets is critical for correct deciphering of desired gene expression differences. RESULTS We(More)
The ADAM (a disintegrin and metalloprotease) family is a group of transmembrane proteins containing cell adhesive and proteolytic functional domains. Microarray analysis detected elevated ADAM9 during the transition of human LNCaP prostate cancer cells from an androgen-dependent to an androgen-independent and metastatic state. Using a prostate tissue array(More)
The class of functors known as discrete Conduché fibrations forms a common generalization of discrete fibrations and discrete opfibrations, and shares many of the formal properties of these two classes. F. Lamarche [7] conjectured that, for any small category B, the category DCF/B of discrete Conduché fibrations over B should be a topos. In this note we(More)