Peter John Connelly

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There is a growing body of evidence that subtle deficits in instrumental activities of daily living (IADL) may be present in mild cognitive impairment (MCI). However, it is not clear if there are IADL domains that are consistently affected across patients with MCI. In this systematic review, therefore, we aimed to summarize research results regarding the(More)
OBJECTIVE To investigate the possibility that response to cholinesterase inhibitor therapy could be predicted by easily measurable variables that are known to change as a result of treatment (such as the Mini Mental State Examination), measures of function (such as the instrumental activities of daily living and the social behaviour subscales of the Nurse's(More)
BACKGROUND People with dementia are extremely vulnerable in hospital and unscheduled admissions should be avoided if possible. AIMS To identify any predictors of general hospital admission in people with dementia in a well-characterised national prospective cohort study. METHOD A cohort of 730 persons with dementia was drawn from the Scottish Dementia(More)
OBJECTIVES A decrease in cholinergic activity is a key event in the biochemistry of Alzheimer's disease (AD). The aim of the study was to investigate the expression levels of markers of cholinergic function in saliva, which is a readily accessible body fluid that can be obtained from subjects with minimal distress. DESIGN AND METHODS Salivary samples were(More)
Current smoking has been suggested as predicting poor response to cholinesterase inhibitor treatment. This observational study compares response in subjects with NINCDS-ADRDA 'probable' Alzheimer's disease who are current smokers and subjects who are non-smokers. Smoking status was not associated with response. Smokers were significantly more likely to(More)
OBJECTIVES (1) to assess the effect of 1 mg folic acid supplementation of cholinesterase inhibitors (ChI) in a 6 month double-blind placebo-controlled study of patients with Alzheimer's Disease (AD) and (2) to assess whether outcome measures were affected by changes in homocysteine levels. METHOD Fifty-seven consecutive outpatients with probable AD were(More)
OBJECTIVE To evaluate how much the Addenbrooke's Cognitive Examination-revised (ACE-R) improves the estimate of cognitive ability from the Mini-Mental State Examination (MMSE) in people with Alzheimer disease (AD). METHODS We examined itemized data in people with AD who were on the Scottish Dementia Research Interest Register drawn from eight centres(More)
Scotland's National Dementia Strategy calls for people with dementia and their carers to give voice to what they see as the priorities for dementia research. We sent questionnaires on dementia research priorities, locus and type of research, desired outcome measures and willingness to volunteer, to two groups of dementia research stakeholders: (1) people(More)