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Atherosclerotic disease of the renal artery can lead to reduction in arterial caliber and ultimately to conditions including renovascular hypertension. Renal artery stenosis is conventionally assessed, using angiography, according to the severity of the stenosis. However, the severity of a stenosis is not a reliable indicator of functional significance, or(More)
Three-dimensional (3-D) angiographic methods are gaining acceptance for evaluation of atherosclerotic disease. However, measurement of vessel stenosis from 3-D angiographic methods can be problematic due to limited image resolution and contrast. We present a method for reconstructing vessel surfaces from 3-D angiographic methods that allows for objective(More)
Renovascular disease is an important cause of hypertension. For assessing treatment options for renovascular disease such as angioplasty or nephrectomy, it is important to characterize the renal tissue. Magnetic resonance (MR) renography is becoming a viable method for characterization of the renal tissue. However, analysis of MR renography is hampered by(More)
Bolus tracking magnetic resonance imaging (MRI) is a powerful technique for measuring perfusion, and is playing an increasing role in the investigation of acute stroke. However, limitations have been reported when assessing patients with steno-occlusive disease. The presence of a steno-occlusive disease in the artery may cause bolus dispersion, which has(More)
RATIONALE AND OBJECTIVES The authors' goal was to develop a noninvasive method for detailed assessment of blood flow patterns from direct in vivo measurements of vessel anatomy and flow rates. MATERIALS AND METHODS The authors developed a method to construct realistic patient-specific finite element models of blood flow in carotid arteries. Anatomic(More)
Tumor size is often determined from computed tomography (CT) images to assess disease progression. A study was conducted to demonstrate the advantages of the fuzzy C-means (FCM) algorithm for volumetric analysis of colorectal liver metastases in comparison with manual contouring. Intra-and interobserver variability was assessed for manual contouring and the(More)
Interpretation of magnetic resonance angiography (MRA) is problematic due to complexities of vascular shape and to artifacts such as the partial volume effect. We present new methods to assist in the interpretation of MRA. These include methods for detection of vessel paths and for determination of branching patterns of vascular trees. They are based on the(More)
Considerable evidence has emerged that adverse blood flow patterns are a major factor in the onset of atherosclerotic disease and may play a role in disease progression. This chapter reviews a technique, referred to as vascular computational fluid dynamics (CFD), for characterizing blood flow patterns in large arteries from magnetic resonance angiography(More)