Peter J. Walter

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OBJECTIVE To measure long-term changes in resting metabolic rate (RMR) and body composition in participants of "The Biggest Loser" competition. METHODS Body composition was measured by dual energy X-ray absorptiometry, and RMR was determined by indirect calorimetry at baseline, at the end of the 30-week competition and 6 years later. Metabolic adaptation(More)
Dietary carbohydrate restriction has been purported to cause endocrine adaptations that promote body fat loss more than dietary fat restriction. We selectively restricted dietary carbohydrate versus fat for 6 days following a 5-day baseline diet in 19 adults with obesity confined to a metabolic ward where they exercised daily. Subjects received both(More)
Nonnutritive sweeteners (NNS), including saccharin, sucralose, aspartame, and acesulfame-potassium, are commonly consumed in the general population, and all except for saccharin are considered safe for use during pregnancy and lactation. Sucralose (Splenda) currently holds the majority of the NNS market share and is often combined with acesulfame-potassium(More)
This is a review of papers presented at the international symposium on ‘Quality of Life after Open Heart Surgery’ comprising the experience in more than 20,000 patients. Early identification and operation of premorbid personalities, psychological counselling before and after the operation, explanation of true risks, an educational programme in redefinition(More)
OBJECTIVE To determine sucralose and acesulfame-K pharmacokinetics in breast milk following maternal ingestion of a diet soda. METHODS Thirty-four exclusively breastfeeding women (14 normal weight, 20 obese) consumed twelve ounces of Diet Rite Cola™, sweetened with 68 mg sucralose and 41 mg acesulfame-potassium, prior to a standardized breakfast meal.(More)
Life expectancy has almost doubled in this century, and by the year 2030 one-quarter of the population will be > 65 years old. It is for science not only to keep adding years to life but, more importantly, to add life to these years. Coronary artery bypass grafting (CABG) embraces these twin goals, and its technical confidence has kept pace in meeting the(More)
Levamisole, an anthelmintic drug with cholinergic properties, has been implicated in cases of drug-induced vasculitis when added to cocaine for profit purposes. Neutrophil extracellular trap (NET) formation is a cell death mechanism characterized by extrusion of chromatin decorated with granule proteins. Aberrant NET formation and degradation have been(More)
Currently, implementation of standard methods for chemical analysis relies upon the expertise of an analyst for conversion of the methods into usable procedures and for reproducible execution of these procedures. One can now encapsulate standard methods in a database format which can be transferred among laboratories. These methods can then be converted(More)
Background: Low-calorie sweeteners (LCSs) are found in many foods and beverages, but consumers may not realize their presence, and their role in appetite, weight, and health is controversial. Although consumption limits based on toxicologic safety are well established, the threshold required to exert clinically relevant metabolic effects is(More)
CONTEXT Individuals with HIV have an elevated risk for developing cardiovascular disease compared to controls, particularly in relationship to abnormal deposition of lipid within various body compartments. Dysregulation of lipolysis may contribute to abnormal deposition of lipid in non-adipose tissues such as the heart, leading to untoward health(More)