Peter J. W. Iles

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— A method is proposed to determine the average cellular geometry in high-resolution images of embryonic epithelia. The concept of a 'composite cell' is used to represent the average cell shape. This composite cell can provide evidence of stresses present in the epithelia. A new adaptive contrast enhancement routine is applied to the input image first,(More)
Recent computational and analytical studies have shown that cellular fabric-as embodied by average cell size, aspect ratio and orientation-is a key indicator of the stresses acting in an embryonic epithelium. Cellular fabric in real embryonic tissues could not previously be measured automatically because the cell boundaries tend to be poorly defined,(More)
— Four computer vision algorithms to measure the average orientation, shape and size of cells in images of biological tissue are proposed and tested. These properties, which can be embodied by an elliptical 'composite cell' are crucial for biomechanical tissue models. To automatically determine these properties is challenging due to the diverse nature of(More)
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