Peter J. Schüffler

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We consider an automated processing pipeline for tissue micro array analysis (TMA) of renal cell carcinoma. It consists of several consecutive tasks, which can be mapped to machine learning challenges. We investigate three of these tasks, namely nuclei segmentation, nuclei classification and staining estimation. We argue for a holistic view of the(More)
BACKGROUND Secreted Wnt signaling antagonists have recently been described as frequent targets of epigenetic inactivation in human tumor entities. Since gene silencing of certain Wnt antagonists was found to be correlated with adverse patient survival in cancer, we aimed at investigating a potential prognostic impact of the two Wnt antagonizing molecules(More)
We propose an information processing pipeline for segmenting parts of the bowel in abdominal magnetic resonance images that are affected with Crohn's disease. Given a magnetic resonance imaging test volume, it is first oversegmented into supervoxels and each supervoxel is analyzed to detect presence of Crohn's disease using random forest (RF) classifiers.(More)
BACKGROUND Histological tissue analysis often involves manual cell counting and staining estimation of cancerous cells. These assessments are extremely time consuming, highly subjective and prone to error, since immunohistochemically stained cancer tissues usually show high variability in cell sizes, morphological structures and staining quality. To(More)
In this paper we propose to use advanced classification techniques with shape features for nuclei classification in tissue microarray images of renal cell carcinoma. Our aim is to improve the classification accuracy in distinguishing between healthy and cancerous cells. The approach is inspired by natural language processing. Several features are extracted(More)
We consider a Multiple Kernel Learning (MKL) framework for nuclei classification in tissue microarray images of renal cell carci-noma. Several features are extracted from the automatically segmented nuclei and MKL is applied for classification. We compare our results with an incremental version of MKL, support vector machines with single kernel (SVM) and(More)
Our proposed method combines semi supervised learning (SSL) and active learning (AL) for automatic detection and segmentation of Crohn's disease (CD) from abdominal magnetic resonance (MR) images. Random forest (RF) classifiers are used due to fast SSL classification and capacity to interpret learned knowledge. Query samples for AL are selected by a novel(More)