Peter J. P. Krause

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Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis were prepared by an expert panel of the Infectious Diseases Society of America. These updated guidelines replace the previous treatment guidelines published in 2000 (Clin Infect Dis(More)
EEG coherence was computed from 19 scalp locations from 189 children ranging in age from 5 to 16 years. Tests of spatial homogeneity of EEG coherence were conducted by comparing EEG coherence as a function of different interelectrode distances in the anterior-to-posterior versus posterior-to-anterior directions. Highly significant inhomogeneities were(More)
Borrelia miyamotoi is distantly related to B. burgdorferi and transmitted by the same hard-body tick species. We report 46 cases of B. miyamotoi infection in humans and compare the frequency and clinical manifestations of this infection with those caused by B. garinii and B. burgdorferi infection. All 46 patients lived in Russia and had influenza-like(More)
From the Departments of Family Medicine and Pediatrics, Connecticut Children’s Medical Center, Hartford, and University of Connecticut Health Center, Farmington (H.M.F.); Microbiology Laboratory, Division of Vector-Borne Infectious Diseases, Centers for Diseases Control and Prevention, Fort Collins, CO (B.J.B.J.); Lyme Borreliosis Unit, Health Protection(More)
n engl j med 368;3 january 17, 2013 291 tory tract infections cautioning against their misuse.3 Linezolid may become subject to similar misuse by physicians who prescribe it for the treatment of undiagnosed infections, as has been reported.4 This observation is consistent with our own at a tertiary care hospital in India. In the recent guidelines(More)
OBJECTIVE The objectives of this quality standard are 1) to provide an implementation mechanism that will facilitate the reliable administration of prophylactic antimicrobial agents to patients undergoing operative procedures in which such a practice is judged to be beneficial and 2) to provide a guideline that will help local hospital committees formulate(More)
OBJECTIVE To determine whether patients coinfected with Lyme disease and babesiosis in sites where both diseases are zoonotic experience a greater number of symptoms for a longer period of time than those with either infection alone. DESIGN Community-based, yearly serosurvey and clinic-based cohort study. SETTING Island community in Rhode Island and 2(More)
We have sequenced the genome of the emerging human pathogen Babesia microti and compared it with that of other protozoa. B. microti has the smallest nuclear genome among all Apicomplexan parasites sequenced to date with three chromosomes encoding ∼3500 polypeptides, several of which are species specific. Genome-wide phylogenetic analyses indicate that B.(More)
Human infection due to Babesia microti has been regarded as infrequent and a condition primarily affecting the elderly or immunocompromised. To determine whether risk in endemic sites may be increasing relative to that of Borrelia burgdorferi and to define its age-related clinical spectrum, we carried out a 10-year community-based serosurvey and case(More)