Peter J. Kos

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BACKGROUND Translational medicine requires the integration of knowledge using heterogeneous data from health care to the life sciences. Here, we describe a collaborative effort to produce a prototype Translational Medicine Knowledge Base (TMKB) capable of answering questions relating to clinical practice and pharmaceutical drug discovery. RESULTS We(More)
This paper demonstrates a method to identify keyword strategies to facilitate the search for articles containing decision support and clinical algorithms represented in the text by complex unsearchable items such as decision tree figures, pseudo code, or mathematical formulae. We use a text mining approach to generate 'Surrogate Algorithm Tags' (SRATs),(More)
Ribonucleotide reductase (RNR) catalyzes the formation of deoxyribonucleotides, a rate limiting step in DNA synthesis. Class I RNR is a tetramer that consists of two subunits, R1 and R2; enzymatic activity requires association of R1 with R2. The R2 subunit is of special interest because it dictates the interaction with R1 that is required for enzymatic(More)
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