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Synthetic RS20 peptide and a set of its point-mutated peptide analogs have been used to analyze the interactions between calmodulin (CaM) and the CaM-binding sequence of smooth-muscle myosin light chain kinase both in the presence and the absence of Ca(2+). Particular peptides, which were expected to have different binding strengths, were chosen to address(More)
BACKGROUND Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders. S100A12 is an important factor in host/parasite defenses and in the inflammatory response. Like several other S100 proteins, it binds zinc and copper in(More)
The Australian and New Zealand Society for Mass Spectrometry (ANZSMS)'s highest award is the ANZSMS Medal. It has only been awarded twice before (Jim Morrison, 2009 and John Bowie, 2011) and recognises " outstanding contributions to knowledge in the biological, chemical, engineering, mathematical , medical or physical sciences relating directly to the(More)
b Editor We decided earlier this year to trial the idea that authors be encouraged to write two Abstracts for their papers, one in their preferred native-language and one in English. For the purposes of this trial, German was picked as the native language. The Editors and Publishers have over the years observed that nuances, which sometimes are very(More)
Curiously journals of mass spectrometry for me always have seemed to have something to do with Australia. I migrated from England to Australia in 1975 to work with one of the eminent " Jim's " in mass spectrometry in Australia—Jim Morrison in Melbourne—and later moved to be with the other " Jim " in mass spectrometry in Australia—Jim Shannon in Sydney.(More)
A novel nano-electrospray emitter has been developed containing two separated channels running throughout the length of the emitter. The emitters have been fabricated from "theta-shaped" borosilicate capillaries. Loading of different solutions into the two different channels opens up the possibility to study short timescale interactions within a Taylor(More)
The Unsung Champions – the chemical elements Oundle School of life and medicines 2 The concept of this biennial Showcase Science was conceived in 1999 and the motivation behind it was to exhibit cutting-edge research in engineering, science and technology to pre-university students. These individuals although embarked on courses involving science, may not(More)
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