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Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory(More)
[1] We develop a spectral inversion method for mass redistribution on the Earth's surface given geodetic measurements of the solid Earth's geometrical shape, using the elastic load Love numbers. First, spectral coefficients are geodetically estimated to some degree. Spatial inversion then finds the continental surface mass distribution that would force(More)
We demonstrate that interspecific sequence conservation can provide a systematic guide to the identification of functional cis-regulatory elements within a large expanse of genomic DNA. The test was carried out on the otx gene of Strongylocentrotus purpuratus. This gene plays a major role in the gene regulatory network that underlies endomesoderm(More)
The widespread use of personal digital assistants and smartphones gives securing these devices a high priority. Yet little attention has been placed on protecting handheld devices against viruses. Currently available antivirus software for handhelds is few in number. At this stage, the opportunity exists for the evaluation and improvement of current(More)
The investigation and modeling of gene regulatory networks requires computational tools specific to the task. We present several locally developed software tools that have been used in support of our ongoing research into the embryogenesis of the sea urchin. These tools are especially well suited to iterative refinement of models through experimental and(More)
The Canadian Study of Health and Aging (CHSA) provided an opportunity to examine the positive aspects of aging. CHSA-2 included the 18-item Ryff multidimensional measure of well-being, which taps six core theoretical dimensions of positive psychological functioning. The measure was administered to 4,960 seniors without severe cognitive impairment or(More)
Many systems are constructed without the use of modeling and visualization artifacts, due to constraints imposed by deadlines or a shortage of manpower. Nevertheless, such systems might profit from the visualization provided by diagrams to facilitate maintenance of the constructed system. In this paper , we present a tool, Reveal, to reverse engineer a(More)
As businesses strive to keep pace with the rapid evolution of web technologies, their efforts to maintain automated regression testing strategies are being hindered. Technological migration of a web application can lead to test scripts becoming incapable of validating the migrated application due to differences in the testing platform. Regression tests that(More)
[1] We test a unified observation model for estimating surface-loading-induced geocenter motion using GPS. In principle, this model is more complete than current methods, since both the translation and deformation of the network are modeled in a frame at the center of mass of the entire Earth system. Real and synthetic data for six different GPS analyses(More)