Peter Hobson

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The Anti-Nuclear Antibody (ANA) clinical pathology test is commonly used to identify the existence of various diseases. A hallmark method for identifying the presence of ANAs is the Indirect Immunofluorescence method on Human Epithe-lial (HEp-2) cells, due to its high sensitivity and the large range of antigens that can be detected. However, the method(More)
This paper describes a novel system for automatic classification of images obtained from Anti-Nuclear Antibody (ANA) pathology tests on Human Epithelial type 2 (HEp-2) cells using the Indirect Immunoflu-orescence (IIF) protocol. The IIF protocol on HEp-2 cells has been the hallmark method to identify the presence of ANAs, due to its high sensitivity and the(More)
Recently, there has been a growing interest in developing Computer Aided Diagnostic (CAD) systems for improving the reliability and consistency of pathology test results. This paper describes a novel CAD system for the Anti-Nuclear Antibody (ANA) test via Indirect Immunofluorescence protocol on Human Epithelial Type 2 (HEp-2) cells. While prior works have(More)
OBJECTIVE This paper presents benchmarking results of human epithelial type 2 (HEp-2) interphase cell image classification methods on a very large dataset. The indirect immunofluorescence method applied on HEp-2 cells has been the gold standard to identify connective tissue diseases such as systemic lupus erythematosus and Sjögren's syndrome. However, the(More)
Identifying the presence of Anti-Nuclear Antibody in Human Epithelial type 2 (HEp-2) cells via Indirect Immunofluores-cence (IIF) is commonly used to diagnose various connective tissue diseases in clinical pathology tests. This pathology test can be automated by computer vision algorithms. However, the existing automated systems, namely Computer Aided(More)
—Indirect Immunofluorescence (IIF) on Human ep-ithelial (HEp-2) cells test has been the golden standard for identifying the presence of Anti-Nuclear Antibodies (ANA) due to its high sensitivity and the large range of antigens that can be detected. Furthermore, IIF ANA test allows the positive sample strength (sample end point titre) to be reported. Despite(More)