Peter Hobson

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AIM To assess cognitive function in elderly subjects with clinically probable Parkinson's disease (PD). METHODS A community sample of 126 patients with probable PD completed the CAMCOG, which is the cognitive section of the Cambridge Examination for Mental Disorders, and the Mini-Mental State Examination (MMSE). The performance of the CAMCOG and the MMSE(More)
The Anti-Nuclear Antibody (ANA) clinical pathology test is commonly used to identify the existence of various diseases. A hallmark method for identifying the presence of ANAs is the Indirect Immunofluorescence method on Human Epithe-lial (HEp-2) cells, due to its high sensitivity and the large range of antigens that can be detected. However, the method(More)
This paper describes a novel system for automatic classification of images obtained from Anti-Nuclear Antibody (ANA) pathology tests on Human Epithelial type 2 (HEp-2) cells using the Indirect Immunoflu-orescence (IIF) protocol. The IIF protocol on HEp-2 cells has been the hallmark method to identify the presence of ANAs, due to its high sensitivity and the(More)
Recently, there has been a growing interest in developing Computer Aided Diagnostic (CAD) systems for improving the reliability and consistency of pathology test results. This paper describes a novel CAD system for the Anti-Nuclear Antibody (ANA) test via Indirect Immunofluorescence protocol on Human Epithelial Type 2 (HEp-2) cells. While prior works have(More)
OBJECTIVE Mild cognitive impairment in Parkinson's disease (PD-MCI) has been suggested to be a predictor for the development of PD dementia (PDD). This study explored the incidence and possible neuropsychological domain differences between PD patients with PD-MCI and without cognitive impairment (normal cognitive function with PD), on the basis of the(More)
OBJECTIVE This paper presents benchmarking results of human epithelial type 2 (HEp-2) interphase cell image classification methods on a very large dataset. The indirect immunofluorescence method applied on HEp-2 cells has been the gold standard to identify connective tissue diseases such as systemic lupus erythematosus and Sjögren's syndrome. However, the(More)
OBJECTIVE To compare survival, life expectancies (LE), and the anticipated age at the time of death (AAD), in a community-based cohort of Parkinson's disease (PD) patients with and without significant cognitive impairment, with an age sex matched population of England and Wales. METHODS The age- and sex-specific standardised mortality ratios (SMR) were(More)
Identifying the presence of Anti-Nuclear Antibody in Human Epithelial type 2 (HEp-2) cells via Indirect Immunofluores-cence (IIF) is commonly used to diagnose various connective tissue diseases in clinical pathology tests. This pathology test can be automated by computer vision algorithms. However, the existing automated systems, namely Computer Aided(More)