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OBJECTIVES To assess the validity of the Parkinson's Disease Quality of Life (PDQL) questionnaire, a patient-specific multi-dimensional quality of life measure, in a community-based sample of patients with Parkinson's disease (PI)) using standardized measures of disease severity, depressive symptomatology and cognitive function. DESIGN A group of 194(More)
BACKGROUND Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in many products and have been detected in human samples worldwide. Limited data show that concentrations are elevated in young children. OBJECTIVES We investigated the association between PBDEs and age with an emphasis on young children from Australia in 2006-2007. METHODS(More)
A catalogue record for this book is available from the British Library Library of Congress Cataloguing in Publication data Parkinson's disease and parkinsonism in the elderly / edited by Jolyon Meara and William C. Koller. p. ; cm. Includes bibliographical references and index. Every effort has been made in preparing this book to provide accurate and(More)
AIM To assess cognitive function in elderly subjects with clinically probable Parkinson's disease (PD). METHODS A community sample of 126 patients with probable PD completed the CAMCOG, which is the cognitive section of the Cambridge Examination for Mental Disorders, and the Mini-Mental State Examination (MMSE). The performance of the CAMCOG and the MMSE(More)
This paper describes a novel system for automatic classification of images obtained from Anti-Nuclear Antibody (ANA) pathology tests on Human Epithelial type 2 (HEp-2) cells using the Indirect Immunofluores-cence (IIF) protocol. The IIF protocol on HEp-2 cells has been the hallmark method to identify the presence of ANAs, due to its high sensitivity and the(More)
The Anti-Nuclear Antibody (ANA) clinical pathology test is commonly used to identify the existence of various diseases. A hallmark method for identifying the presence of ANAs is the Indirect Immunofluorescence method on Human Epithelial (HEp-2) cells, due to its high sensitivity and the large range of antigens that can be detected. However, the method(More)
Recently, there has been a growing interest in developing Computer Aided Diagnostic (CAD) systems for improving the reliability and consistency of pathology test results. This paper describes a novel CAD system for the Anti-Nuclear Antibody (ANA) test via Indirect Immunofluorescence protocol on Human Epithelial Type 2 (HEp-2) cells. While prior works have(More)
OBJECTIVE This paper presents benchmarking results of human epithelial type 2 (HEp-2) interphase cell image classification methods on a very large dataset. The indirect immunofluorescence method applied on HEp-2 cells has been the gold standard to identify connective tissue diseases such as systemic lupus erythematosus and Sjögren's syndrome. However, the(More)