Peter Hoar

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An improved technique to record high-equality electrocardiographic (ECG) signals on the surface, from immersed humans during rest and exercise, in both normothermic and hypothermic exposures, has been devised. Recorded tracings were adequate for research purposes. Waveform signals obtained allow accurate continuous monitoring as well. The best recordings(More)
Perioperative hemodynamic changes following mitral valve replacement using the porcine heterograft prosthesis were measured in 21 patients with acquired mitral valve disease. Preoperatively, a state of compensatory cardiac failure was suggested by the following: an increased heart rate (HR) (96 beats per minute); low cardiac and stroke volume (SVI) indices(More)
Seven of 12 patients (58%) undergoing myocardial revascularization surgery became hypertensive in the immediate postoperative period. The hypertensive patients had significant elevations in peripheral vascular resistance (22.0 +/- 2.0 S.E. resistance units) compared to measurements in normotensive patients (15.6 +/- 1.3 S.E. resistance units) (p less than(More)
Systemic hypertension has been reported as common during coronary artery bypass surgery. The coronary-prone Type A behavior pattern has been associated with heightened reactivity of the sympathetic nervous system. Therefore, the possible relationships between the two was explored. Significant correlations were found between systolic blood pressure rise(More)
The cardiovascular effects of an intravenous nitroprusside infusion were evaluated intraoperatively in seven patients with pure mitral stenosis and seven patients with predominant mitral stenosis. Prior to therapy the adverse hemodynamic consequences of light anesthesia and surgical stimulation were evident in all patients: systemic and/or pulmonary(More)
To compare the hemodynamic effect of vasodilator therapy on different regurgitant lesions, we infused sodium nitroprusside intraooperatively in 12 patients with mitral regurgitation and 15 with aortic regurgitation. During the critical period preceding establishment of cardiopulmonary bypass, both groups had developed intense vasoconstriction and cardiac(More)
Data were collected from 17 patients with valvular regurgitation and ventricular failure who were about to undergo prosthetic replacement of an insufficient cardiac valve. Awake control hemodynamic measurements revealed that these patients came to the operating room with a high systemic vascular resistance of 38 units and low cardiac and stroke volume(More)
To assess the adequacy of tissue perfusion during low-flow, moderately hypothermic cardiopulmonary bypass (CPB), we measured whole-body oxygen consumption (VO2), serum lactate concentrations, and acid-base balance in 12 men undergoing myocardial revascularization. When perfusion flow rate was kept at control levels (2.1 L/min/m2), decreasing the patient's(More)