Peter Hingley

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An analysis was made of data from potency tests on fifteen batches of monovalent foot-and-mouth disease vaccine, comprising five batches each of type O, type A and type C. Regressions were calculated for the relation of percentage protection (probit) versus log 140S antigen dose and for the serum neutralizing antibody titre (log SN50) versus log 140S(More)
The Permanent Commission of O.I.E. on foot and mouth disease has proposed a series of potency standards for foot and mouth disease vaccines. No totally in vitro assay has yet been developed to satisfy these requirements, and most Control Authorities require a potency assay to be carried out in cattle using challenge with virulent virus. There are various(More)
The use of tests in cattle remains the basis for evaluating the potency of foot and mouth disease (FMD) vaccines intended for use in cattle. To be able to compare different types of potency test it is essential to have a good understanding of how measurable responses in cattle to vaccination relate to one another. In this paper the interrelationships were(More)
A method is described for converting a mean serum neutralizing antibody titre after primary vaccination directly into a percentage protection value using a single regression slope. This has advantages over the indirect method in which a potency value is first estimated on the log antigen dose scale before conversion to a percentage protection value, since(More)
A three parameter logistic model is described for the analysis of profiles of optical density vs log dose for indirect sandwich ELISA tests in foot and mouth disease. The model describes the observed phenomenon of saturability with increasing dose, and its parameters can be interpreted in terms of molecular binding events. A computer program to fit the(More)
Sigmoid saturation curves were fitted to the results of titrations of antiserum to foot and mouth disease virus against homologous and heterologous virus strains. Differentiation of strains was readily evident from the different levels of the homologous and heterologous curves. These differences could be quantified by comparison of the saturation curve(More)
Some vaccines can be assayed for potency by measuring the serum antibody response they produce in vaccinated test animals. Using data obtained from potency assays on batches of foot and mouth disease vaccine, the sources of variability in such a method were examined. A linear model is proposed for the analysis of replicate serum neutralizing antibody(More)