Peter H. M. Jacobs

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Organizations increasingly use collaborative teams in order to create value for their stakeholders. This trend has given rise to a new research field: Collaboration Engineering. The goal of Collaboration Engineering is to design and deploy processes for high-value recurring collaborative tasks, and to design these processes such that practitioners can(More)
Most discrete event simulation environments are based on a process-oriented, and therefore multi-threaded paradigm. This results in simulation environments that are very hard to distribute over more computers, and not easy to integrate with scattered external information sources. The architecture presented here is based on the event-based DES paradigm which(More)
BACKGROUND The value of intensive combination therapy in early rheumatoid arthritis is unproven. In a multicentre, double-blind, randomised trial (COBRA), we compared the combination of sulphasalazine (2 g/day), methotrexate (7.5 mg/week), and prednisolone (initially 60 mg/day, tapered in 6 weekly steps to 7.5 mg/day) with sulphasalazine alone. METHODS(More)
In order to support the conceptualization and specification of simulation models of complex systems, several <i>formalisms</i> or <i>world views</i> exist. Petri nets, differential equations, discrete event system specification and process interaction are typical examples. Throughout the last decade many have attempted to implement the <i>process(More)
Huntington's disease (HD) is a progressive neurological disorder characterised by motor impairments caused by degeneration in the striatum. The mechanism by which the HD mutation leads to the neurodegenerative pathology of HD is still unknown. Recently it was shown that, in HD patients, early pathological changes in white matter precede selective cell death(More)
Most discrete event simulation environments are based on a process-oriented, and therefore multi-threaded paradigm. This results in simulation environments that are very hard to distribute over more computers, and not easy to integrate with scattered external information sources. The architecture presented here is based on the event-based DES paradigm which(More)
Information technology innovations, like web-services and object-oriented design, are fast finding their way into Business Information Systems (BIS). At the time similar developments in the field of business system simulation do not gain momentum. This observation, combined with research needs, has been the starting point for the development of an open,(More)
We present a specification of the optimization of KLM's flight schedule in this paper using object-oriented simulation services on top of the Java-based distributed simulation environment DSOL. The paper shows the added value of a service-based architecture for linking the simulation of KLM's operations, the operational modules for day-to-day flight(More)
Manufacturing control systems are extremely hard to design and test. Testing Programmable Logic Controller (PLC) software in an on-line manufacturing setting can be costly, dangerous, and inefficient. The availability of a seamless transition between the real manufacturing process and a simulated manufacturing process on the one hand, and a real PLC and a(More)