Peter H. M. Jacobs

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Organizations increasingly use collaborative teams in order to create value for their stakeholders. This trend has given rise to a new research field: Collaboration Engineering. The goal of Collaboration Engineering is to design and deploy processes for high-value recurring collaborative tasks, and to design these processes such that practitioners can(More)
Huntington's disease (HD) is a progressive neurological disorder characterised by motor impairments caused by degeneration in the striatum. The mechanism by which the HD mutation leads to the neurodegenerative pathology of HD is still unknown. Recently it was shown that, in HD patients, early pathological changes in white matter precede selective cell death(More)
Monomeric and oligomeric procyanidins present in cocoa liquors and chocolates were separated and quantified in four different laboratories using a normal-phase high-performance liquid chromatography (HPLC) method with fluorescence detection. Procyanidin standards through decamers were obtained by extraction from cocoa beans, enrichment by Sephadex LH-20 gel(More)
In order to support the conceptualization and specification of simulation models of complex systems, several <i>formalisms</i> or <i>world views</i> exist. Petri nets, differential equations, discrete event system specification and process interaction are typical examples. Throughout the last decade many have attempted to implement the <i>process(More)
Most discrete event simulation environments are based on a process-oriented, and therefore multi-threaded paradigm. This results in simulation environments that are very hard to distribute over more computers, and not easy to integrate with scattered external information sources. The architecture presented here is based on the event-based DES paradigm which(More)
We present a specification of the optimization of KLM's flight schedule in this paper using object-oriented simulation services on top of the Java-based distributed simulation environment DSOL. The paper shows the added value of a service-based architecture for linking the simulation of KLM's operations, the operational modules for day-to-day flight(More)
Manufacturing control systems are extremely hard to design and test. Testing Programmable Logic Controller (PLC) software in an on-line manufacturing setting can be costly, dangerous, and inefficient. The availability of a seamless transition between the real manufacturing process and a simulated manufacturing process on the one hand, and a real PLC and a(More)
In this paper we present an architecture for internet-mediated simulation games. The challenge was to use today's state of the art technologies to provide a simulated environment for decision making for which the users are trained. Current technologies provide a means to construct a more realistic environment and to embed algorithms for operational decision(More)
Filtration capacity and feeding behaviour has been intensely studied for adult mussels (Mytilus edulis), but less information is available for juvenile mussels (1.5–25 mm, <1 year), especially in natural sea water. The recent introduction of mussel seed collectors in the Netherlands prompted the need for more detailed information on juvenile mussel(More)