PURPOSE The objective was to systematically review clinical trial data on the effects of statins on high-density lipoproteins (HDL) and to examine the possibility that this provides cardiovascular benefits in addition to those derived from reductions in low-density lipoproteins (LDL). METHODS The PubMed database was searched for publications describing… (More)
BACKGROUND The complex pathology of disease has sparked the development of novel protein expression profiling techniques that require validation in clinical settings. This study focuses on multiplexed analyses of adipocytokines and biomarkers linked to the metabolic syndrome, diabetes, and cardiovascular disease. METHODS Multiplexed immunoassays using… (More)
BACKGROUND Evidence-based randomized clinical trials have shown significant benefit of statin treatment with regard to cardiovascular disease. In anticipation of the National Cholesterol Education Program Adult Treatment Panel IV guidelines, we wanted to assess the current state of lipid goal attainment in the high-risk secondary prevention population in… (More)
BACKGROUND Hypothermia related to anaesthesia and operating theatre environment is associated with increased blood loss in a number of surgical disciplines, including total hip arthroplasty. The influence of patient temperature on blood loss in total knee arthroplasty (TKA) has not been previously studied. METHODS We recorded patient axillary temperature… (More)
Knowledge management (KM) has received extensive business press over the last two years, and offers substantial promise for long-tern gains in competitiveness and organizational effectiveness. Due to both hype and interest, the field has expanded greatly, making it difficult to understand what's KM, what's worthwhile, and understanding how it might benefit… (More)
OBJECTIVE The objective of this study was to evaluate the long-term efficacy of adding fenofibric acid to moderate-dose statin therapy in patients at goal for low-density lipoprotein cholesterol (LDL-C) but with persistent hypertriglyceridemia. METHODS This is a post hoc analysis of a subset of patients (N = 92) with mixed dyslipidemia treated with… (More)
This extended abstract describes the workshop Cognition and Collaboration - Analyzing Distributed Community Practices for Design, the Third International Workshop on Analyzing Collaborative Activity.