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Quantitative examination of prostate histology offers clues in the diagnostic classification of lesions and in the prediction of response to treatment and prognosis. To facilitate the collection of quantitative data, the development of machine vision systems is necessary. This study explored the use of imaging for identifying tissue abnormalities in(More)
Topographic mapping of brain electrical activity has become a commonly used method in the clinical as well as research laboratory. To enhance analytic power and accuracy, mapping applications often involve statistical paradigms for the detection of abnormality or difference. Because mapping studies involve many measurements and variables, the appearance of(More)
Ion channels and membrane receptors are vital to many physiological processes. They help cells communicate with each other, to secrete and absorb products, and initiate signalling pathways. The Health Innovations Research Institute's Ion Channels and Transporters as Therapeutic Targets Program uses state-of-the-art electrophysiology, molecular biology and(More)
We illustrate the application of significance probability mapping (SPM) to the analysis of topographic maps of spectral analyzed EEG and visual evoked potential (VEP) activity from patients with brain tumors, boys with dyslexia, and control subjects. When the VEP topographic plots of tumor patients were displayed as number of standard deviations from a(More)
We describe a method for the diagnosis of dyslexia based upon a study of electroencephalographic and evoked potential data recorded from 13 normal and 11 dyslexic boys. Measurements were made from topographic maps of brain electrical activity recorded during resting and activated testing conditions. Using a statistically based technique, we developed rules(More)
Electroencephalographic (EEG) and evoked potential data were recorded during behavioral testing from 8 dyslexic and 10 normal boys aged 9 to 11 years. Topographic mapping of their brain electrical activity revealed four discrete regions of difference between the two groups involving both hemispheres, left more than right. Aberrant dyslexic physiology was(More)
Principal components analysis (PCA) was performed on the 1536 spectral and 2944 evoked potential (EP) variables generated by neurophysiologic paradigms including flash VER, click AER, and eyes open and closed spectral EEG from 202 healthy subjects aged 30 to 80. In each case data dimensionality of 1500 to 3000 was substantially reduced using PCA by(More)
AIM To develop an expert system model for the diagnosis of fine needle aspiration cytology (FNAC) of the breast. METHODS Knowledge and uncertainty were represented in the form of a Bayesian belief network which permitted the combination of diagnostic evidence in a cumulative manner and provided a final probability for the possible diagnostic outcomes. The(More)
Inference networks permit the combining of diagnostic evidence in such a fashion that the mutual dependence structure of different pieces of evidence is considered, and that a probabilistic measure of the uncertainty of the final diagnostic decision is provided. Operated in an automatic reasoning mode, an inference network allows a decoupling of the false(More)