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Background: Age-related macular degeneration (ARMD) is caused by abnormal retinal pigment epithelium (RPE) and may be complicated by choroidal neovascularization. The object of treatment would be to replace the diseased RPE with normal human RPE. • Method: Five patients with ARMD (preoperative visual acuity 0.08–0.2) underwent removal of subretinal(More)
1. Blue, green, and red sensitive cone mechanisms have been studied in two types of on-centre ganglion cells in the Rhesus monkey's retina.2. One type of cell receives signals from both green and red sensitive cone mechanisms, both of which excite in the centre and inhibit in the periphery of the cell's receptive field. These cells discharge transiently to(More)
Retinol-binding protein (RBP) is the sole specific transport protein for retinol (vitamin A) in the circulation, and its single known function is to deliver retinol to tissues. Within tissues, retinol is activated to retinoic acid, which binds to nuclear receptors to regulate transcription of >300 diverse target genes. In the eye, retinol is also activated(More)
Heterotrimeric guanosine 5'-triphosphate (GTP)-binding proteins (G proteins) are deactivated by hydrolysis of the GTP that they bind when activated by transmembrane receptors. Transducin, the G protein that relays visual excitation from rhodopsin to the cyclic guanosine 3',5'-monophosphate phosphodiesterase (PDE) in retinal photoreceptors, must be(More)
The human cone electroretinogram gradually increases in amplitude an average of 75% (range 23 to 157%) during light adaptation, over a period of approximately 20 min. This increase involves both the a- and b-wave components of this response, and both waves follow a similar time course, implying that the photoreceptors themselves are responsible for the(More)
• A study was carried out to investigate whether human RPE allografts are tolerated or rejected in the subretinal space and to determine the feasibility of RPE transplantation in subjects with age-related macular degeneration (AMD). • Methods: Patches of human fetal RPE (13–20 weeks of gestational age) were transplanted into the subretinal space of five(More)
We have used ganzfeld stimulation, selective chromatic adaptation and computer averaging to identify three cone mechanisms in the corneal ERG of the macaque monkey. On a strong yellow background, two cone mechanisms can be distinguished. One has a peak spectral sensitivity near 460 nm with a relatively slow b-wave to light onset and a negative wave at(More)
PURPOSE To examine the S-cone ERG in subjects with and without L and M-cone function. METHODS Ganzfeld spectral flashes in the presence of strong Ganzfeld adapting fields are used to elicit S-cone ERGs. RESULTS The S-cone ERG b-wave ranges from 0.2 to 4 mV in amplitude and 38-45 msec in implicit time. There is a progressive decrease in amplitude with(More)
An unusual retinal degeneration considered to be inherited as an autosomal recessive trait occurred in two of four children in a Hispanic family. The abnormality causes a progressive and generalized loss of cone vision, including decreased acuity, decreased color vision, central scotomas to small test objects, photo-phobia, and a profound diminution of the(More)
An electroretinographic response of the human short wavelength (S) cone system can be distinguished from that of the longer wavelength (L or M) cone system by using ganzfeld short-wavelength stimulation at relatively high levels of retinal adaptation. The S cone response has both an a- and b-wave component in its ERG, both of which are slower than those of(More)