Peter Germann

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In patients with acute respiratory distress syndrome (ARDS), permissive hypercapnia is a strategy to decrease airway pressures to prevent ventilator-induced lung damage by lowering tidal volumes and tolerating higher arterial carbon dioxide tension. However, in experimental studies hypercapnia impairs myocardial contractility and hemodynamic function. We(More)
Data show that carbon monoxide (CO) exerts direct antiinflammatory effects in vitro and in vivo after LPS challenge in a mouse model. We hypothesized that CO may act as an antiinflammatory agent in human endotoxemia. The aim of this trial was to study the effects of CO inhalation on cytokine production during experimental human endotoxemia. The main study(More)
CONTEXT Perioperative antibiotic prophylaxis during elective cesarean delivery at term to reduce postoperative maternal infectious morbidity is generally used but may not be effective on the basis of the available data. Also, the optimal timing of prophylactic antibiotic administration is unclear. OBJECTIVE To compare the effectiveness of cefazolin(More)
HINTERGRUND: Im letzten Jahrzehnt gab es gewaltige Fortschritte beim Transport von kritisch kranken Patienten im Krankenhaus. Obwohl der innerklinische Transport heutzutage als Kontinuum der Intensivbetreuung angesehen wird, stellt dieser immer noch ein spezielles Risiko für die Patienten dar. METHODIK: Diese prospektive Beobachtungsstudie hatte das Ziel,(More)
BACKGROUND The response to inhaled nitric oxide and prone positioning was investigated in 47 patients with adult respiratory distress syndrome to test the hypothesis that inhalation of nitric oxide when in the prone position would result in additive improvement in oxygenation. METHODS The authors prospectively studied patients of both genders who were 15(More)
The excessive uncontrolled activation of inflammatory cells and mediators after trauma or major surgery plays a key role in the development of adult respiratory distress syndrome and multiple organ system failure (MOSF). In the past elevated cytokine levels were shown to influence the outcome of these patients adversely. There are diverging results(More)
Fulminantes Leberversagen stellt eine interdis ziplinäre medizinische Herausforderung dar. Trotz den Verbesserungen in der Intensivmedizin bleibt die Mortalität mit bis zu 80% aufgrund der Komplikationen wie Hirnödem, Sepsis und Multiorganversagen hoch. Die einzige kurative Therapie für Patienten mit fulminantem Leberversagen, bei denen eine spontane(More)
Inhaled nitric oxide (iNO) has been used for treatment of acute respiratory failure and pulmonary hypertension since 1991 in adult patients in the perioperative setting and in critical care. This contribution assesses evidence for the use of iNO in this population as presented to a expert group jointly organised by the European Society of Intensive Care(More)
BACKGROUND Pulmonary hypertension is a frequent complication of severe chronic obstructive pulmonary disease (COPD) and a major cause of morbidity and mortality in this condition. Based on the improved survival of these patients due to long term oxygen therapy and the potent and selective pulmonary vasodilation by inhaled nitric oxide, the safety and(More)
BACKGROUND Effective treatment and prevention of hyperthermia and shivering-like tremor during labor is hindered by a poor understanding of their causes. The authors sought to identify the incidence of nonthermoregulatory shivering-like tremor and the factors associated with this activity. METHODS The authors studied women in spontaneous full-term labor(More)