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A double-blind, randomized, active placebo-controlled pilot study was conducted to examine safety and efficacy of lysergic acid diethylamide (LSD)-assisted psychotherapy in 12 patients with anxiety associated with life-threatening diseases. Treatment included drug-free psychotherapy sessions supplemented by two LSD-assisted psychotherapy sessions 2 to 3(More)
We compared the capillary blood-cell velocity in the fingertips of 30 patients with high-tension glaucoma, 30 patients with normal-tension glaucoma, and 30 control subjects by nailfold capillaroscopy. There were no measurable differences in the morphologic findings. The blood-flow velocity, however, was reduced significantly in the patients with(More)
OBJECTIVE A recently published study showed the safety and efficacy of LSD-assisted psychotherapy in patients with anxiety associated with life-threatening diseases. Participants of this study were included in a prospective follow-up. METHOD 12 months after finishing LSD psychotherapy, 10 participants were tested for anxiety (STAI) and participated in a(More)
BACKGROUND The potent vasoconstrictor peptide endothelin-1 has been shown to participate in the control of peripheral vascular tone and in the regulation of ocular perfusion. In glaucoma patients vasospasms and arterial hypotension have been identified as risk factors for the progression of glaucomatous damage, and the regulation of endothelin-1 release is(More)
BACKGROUND Glaucoma and cataract are multifactorial diseases. They have been described to be associated with cardiovascular risk factors. METHODS Twenty-four-hour ECG monitoring was done in 22 normal-tension glaucoma patients, 27 open-angle glaucoma patients, 25 cataract patients, and 20 normal controls. The frequency of silent myocardial ischemia (SMI)(More)
BACKGROUND After no research in humans for >40 years, there is renewed interest in using lysergic acid diethylamide (LSD) in clinical psychiatric research and practice. There are no modern studies on the subjective and autonomic effects of LSD, and its endocrine effects are unknown. In animals, LSD disrupts prepulse inhibition (PPI) of the acoustic startle(More)
Using capillary videomicroscopy of the nail fold, the frequency of cold-induced vasospasm and capillary hemodynamic parameters were studied after application of cold in 50 patients with primary fibromyalgia, 50 patients with chronic low back pain, and 50 healthy controls. Cold-induced vasospasm was detected in 38% of the patients with fibromyalgia. In this(More)
In order to learn the prevalence of cold-induced vasospasm in migraine patients, blood cell velocity measurements of finger nailfold capillaries were performed in 58 consecutive patients suffering from migraine with and without aura. In 5 (8.6%) patients capillaroscopy could not be performed because of reduced nailfold transparency; 21 of the remaining 53(More)
The typical morphological and consequent functional damage caused by disease entities covered by the term 'glaucoma' is the result of inadequate circulation to the optic nerve fibres, predominantly in the papillary region, as a result of elevated intraocular pressure. The aim of this study is classification of different forms of glaucoma on the basis of(More)