Peter G. Edwards

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AMD3100 is a potent and selective antagonist of the CXCR4 receptor; it has been shown to block the route of entry of HIV into host T-cells. This compound and its analogues have since been found to act as haematopoietic stem cell mobilisation agents and, more recently, as anti-cancer agents. Here, we have examined a fluorescent derivative of AMD3100, L(1),(More)
The synthesis of the novel ligand tris(2,2'-bipyrid-6-yl) methanol (L(1)) is described. Co-ordination of the ligand to the first row transition metals (Mn(2+)-Zn(2+)) as well as Cd(2+) showed that the ligand formed complexes close to trigonal prismatic in geometry in the solid state. Analysis of the geometry of the co-ordination spheres showed varying(More)
We report two tripodal frameworks, mono(2,2'-bipyrid-6-yl)bis(2-pyridyl)methanol () and bis(2,2'-bipyrid-6-yl)mono(2-pyridyl)methanol () which have one and two bipyridyl arms, respectively. Both ligands form complexes with the first row transition metals. Both ligands appear to overcome the steric strain involved in twisting the ligand to produce an(More)
Palladium complexes of a series of functionalised phosphines bearing the OPN donor set [2-pyCH(2)P(Ph)CH(2)(CHOCH(2)CH(2)CH(2)), 1; 2-py CH(2)P(Ph)-CH(2)CH(2)(CHOCH(2)CH(2)O), 2; 2-pyCH(2)P(Ph)CH(2)CH(2)CO(2)Me, 3; 2-pyP(Ph)CH(2)(CHOCH(2)CH(2)CH(2)), 4; 2-py = 2-pyridyl] have been prepared and characterised. Ligands 1-3 form five membered P-N chelates which(More)
The 2,6-dixylyl-4-phenylphosphabarrelene has been synthesised from the parent phosphinine and its properties as a ligand explored through the preparation and characterisation of the complexes W(CO)(5)(L), Re(CO)(4)(L)Cl, (eta(6)-cymene)RuCl(2)(L), [(eta(5)-Me(3)SiC(5)H(4))Fe(CO)(2)(L)]PF(6), Rh(1,5-COD)(L)Cl, Ir(1,5-COD)(L)Cl, and cis-Pt(L)(2)Cl(2), where L(More)
Poly-NHC (NHC = N-heterocyclic carbene) ligands emerged almost immediately after the first stable NHCs had been described. Macrocyclic ligands, featuring NHC donor groups and their metal complexes, however, remained rare until recently. This perspective highlights modern developments in the fields of synthesis and coordination chemistry of macrocyclic(More)
Racemic trans-1,2-diphosphinocyclohexane (t-chxnP2) has been synthesised and its coordination chemistry to Cu(I), Ag(I), Mn(I) and Fe(II) investigated. Compounds of empirical formula [Cu(t-chxnP2)2]BF4 and [Ag(t-chxnP2)2]BF4 have been prepared as isomeric mixtures and the solid-state structure of both complexes determined by single-crystal techniques. The(More)
Nine-membered 1,4,7-triphospha- and triarsamacrocycles with unsaturated benzo-backbones have been prepared using the [Cp(R)Fe](+) unit as a template. The cyclisation involves the attack of a coordinated phosphide (or arsenide) nucleophile at an activated, electrophilic ortho-fluorophenyl substituent on a neighbouring pnictide donor. The macrocycle assembly(More)
Primary and secondary phosphine piano-stool complexes of the type [eta(5)-CpFeL3]+ (L = phenylphosphine, 3, (alpha-methyl)vinylphosphine, 4, allylphosphine, 5, (2-methylpropenyl)phosphine, 5b, allyl(phenyl)phosphine, 6) are described. The alkenyl phosphine complexes, 5 and 6, react by intramolecular hydrophosphination to give the corresponding(More)
Rhenium complex []Cl with the coordinated [11]ane-P(2)C(NHC) macrocycle was obtained by a metal template controlled ring formation reaction; in this reaction a coordinated NH,NH-stabilised imidazolidin-2-ylidene ligand was connected via the nitrogen atoms to two phenyl substituents of a 2-fluorophenyl substituted diphosphine ligand.