Peter G. Edwards

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AMD3100 is a potent and selective antagonist of the CXCR4 receptor; it has been shown to block the route of entry of HIV into host T-cells. This compound and its analogues have since been found to act as haematopoietic stem cell mobilisation agents and, more recently, as anti-cancer agents. Here, we have examined a fluorescent derivative of AMD3100, L(1),(More)
The synthesis of N-heterocyclic carbene-diphosphine macrocycles by metal template assisted cyclization reactions has been explored. Attempts to prepare the facial tungsten tricarbonyl precursor complex containing an NH,NH-functionalized carbene and a suitable diphosphine resulted in displacement of the coordinated carbene and the isolation of the(More)
The synthesis of the novel ligand tris(2,2'-bipyrid-6-yl) methanol (L(1)) is described. Co-ordination of the ligand to the first row transition metals (Mn(2+)-Zn(2+)) as well as Cd(2+) showed that the ligand formed complexes close to trigonal prismatic in geometry in the solid state. Analysis of the geometry of the co-ordination spheres showed varying(More)
The tripodal bipyridine-based ligand tris(2,2’-bipyrid-6-yl) methanol (L 1 ) was shown in our previous work to have a strong steric preference for trigonal prismatic co ordination environments with a series of transition metals. We now report the crystal structure of the ligand framework, isolated in its monoprotonated form with a perchlorate counterion.(More)
A tripodal tris-8-aminoquinoline ligand was synthesised in high yield via the Bucherer reaction. The septa-dentate ligand was found to give isolable complexes when coordinated with transition metals. Complexes of zinc(ii), cadmium(ii) and cobalt(iii) were isolated and their solid state structures were determined by single crystal X-ray diffraction. The(More)
Racemic trans-1,2-diphosphinocyclohexane (t-chxnP2) has been synthesised and its coordination chemistry to Cu(I), Ag(I), Mn(I) and Fe(II) investigated. Compounds of empirical formula [Cu(t-chxnP2)2]BF4 and [Ag(t-chxnP2)2]BF4 have been prepared as isomeric mixtures and the solid-state structure of both complexes determined by single-crystal techniques. The(More)
The synthesis of Re(), Re() and Mn() compounds of the macrocyclic phosphine ligand 1,5,9-trialkyl-1,5,9triphosphacyclododecane, 12[ane]P3R3 (R = Et, Bu) is described. The reaction of 12[ane]P3R3 with ReCl3(PPh3)2(CH3CN) or ReCl3(PPhMe2)3 gives rise to the octahedral d 4 complexes (12[ane]P3R3)ReCl3 (1 ). Reduction of 1 with Na/Hg under a CO atmosphere(More)
Poly-NHC (NHC = N-heterocyclic carbene) ligands emerged almost immediately after the first stable NHCs had been described. Macrocyclic ligands, featuring NHC donor groups and their metal complexes, however, remained rare until recently. This perspective highlights modern developments in the fields of synthesis and coordination chemistry of macrocyclic(More)
The reaction of the manganese precursors [MnOTf(CO)3{1,2-(PH2)2C6H4}], 5, or [MnOTf(CO)3{1,2-(PH2)2C2H4}], 6, with either the silver complex of 1,3-diallylbenzimidazol-2-ylidiene or the free carbene, resulted in the formation of the new, dimeric phosphino-micro-phosphido manganese species 7 and 8. Complex 7 crystallises in two isomeric forms (cis and(More)
1-Trimethylsilylphosphirane, C2H4PSiMe3, has been prepared on a multi gram scale from P(SiMe3)3 via CICH2CH2P(SiMe3)2. C2H4PSiMe3 is readily susceptible to protonolysis forming the thermally unstable parent phosphirane, C2H4PH, in good yields. Reaction of C2H4PSiMe3 with fac-M(CO)3(CH3CN)3 (M = Cr, Mo) or [Fe(eta5-C5H5)(eta6-C6H6)](PF6) give rise(More)