Peter G Davis

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BACKGROUND Newborn animal and human pilot studies suggest that mild hypothermia following peripartum hypoxia-ischaemia in newborn infants may reduce neurological sequelae, without adverse effects. OBJECTIVES To determine whether therapeutic hypothermia in encephalopathic asphyxiated newborn infants reduces mortality and long-term neurodevelopmental(More)
BACKGROUND Bronchopulmonary dysplasia is associated with ventilation and oxygen treatment. This randomized trial investigated whether nasal continuous positive airway pressure (CPAP), rather than intubation and ventilation, shortly after birth would reduce the rate of death or bronchopulmonary dysplasia in very preterm infants. METHODS We randomly(More)
BACKGROUND Methylxanthines reduce the frequency of apnea of prematurity and the need for mechanical ventilation during the first seven days of therapy. It is uncertain whether methylxanthines have other short- and long-term benefits or risks in infants with very low birth weight. METHODS We randomly assigned 2006 infants with birth weights of 500 to 1250(More)
OBJECTIVE The goal was to define reference ranges for pulse oxygen saturation (Spo(2)) values in the first 10 minutes after birth for infants who received no medical intervention in the delivery room. METHODS Infants were eligible if a member of the research team was available to record Spo(2) immediately after birth. Infants were excluded if they(More)
The purpose of this study was to determine the effect of aerobic exercise duration on plasma protein carbonyl concentrations, a marker of protein oxidation, in aerobically trained men and women. Eight men (age: 27 +/- 4 years, VO (2peak): 4.09 +/- 0.26 L x min (-1); mean +/- SD) and 7 women (age: 27 +/- 6 years, VO (2peak): 2.33 +/- 0.24 L x min (-1))(More)
A comparison was made of annual net ecosystem productivity (NEP) of a closed canopy Sitka spruce forest over 2 years, using either eddy covariance or inventory techniques. Estimates for annual net uptake of carbon (C) by the forest varied between 7.30 and 11.44 t C ha−1 year−1 using ecological inventory (NEPeco) measures and 7.69–9.44 t C ha−1 year−1 using(More)
CONTEXT Uncertainty exists about the benefit of dietary docosahexaenoic acid (DHA) on the neurodevelopment of preterm infants. OBJECTIVE To determine the effect of meeting the estimated DHA requirement of preterm infants on neurodevelopment at 18 months' corrected age. DESIGN, SETTING, AND PARTICIPANTS Randomized, double-blind controlled trial enrolling(More)
OBJECTIVE In preterm infants, chronic lung disease (CLD) is associated with an increased risk for cerebral palsy (CP). However, systemic postnatal corticosteroid therapy to prevent or treat CLD, although effective in improving lung function, may cause CP. The objective of this study was to determine the effect of systemic postnatal corticosteroid treatment(More)
BACKGROUND Damage caused by lung overdistension (volutrauma) has been implicated in the development bronchopulmonary dysplasia (BPD). Modern neonatal ventilation modes can target a set tidal volume as an alternative to traditional pressure-limited ventilation using a fixed inflation pressure. Volume targeting aims to produce a more stable tidal volume in(More)
From the Newborn Research Centre, Royal Women’s Hospital (B.J.M., L.S.O., L.W.D., P.G.D.), the Departments of Obstetrics and Gynaecology (B.J.M., L.S.O., L.W.D., P.G.D.) and Paediatrics (L.W.D., S.M.D.), University of Melbourne, and the Critical Care and Neurosciences Theme (B.J.M., L.S.O., L.W.D., P.G.D.) and Clinical Epidemiology and Biostatistics Unit(More)