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- Publications
- Influence
Active genes dynamically colocalize to shared sites of ongoing transcription
- C. Osborne, L. Chakalova, +8 authors Peter Fraser
- Biology, Medicine
- Nature Genetics
- 1 October 2004
The intranuclear position of many genes has been correlated with their activity state, suggesting that migration to functional subcompartments may influence gene expression. Indeed, nascent RNA… Expand
Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
- S. Schoenfelder, T. Sexton, +13 authors Peter Fraser
- Biology, Medicine
- Nature Genetics
- 2010
The discovery of interchromosomal interactions in higher eukaryotes points to a functional interplay between genome architecture and gene expression, challenging the view of transcription as a… Expand
Single cell Hi-C reveals cell-to-cell variability in chromosome structure
- T. Nagano, Yaniv Lubling, +6 authors Peter Fraser
- Biology, Medicine
- Nature
- 25 September 2013
Large-scale chromosome structure and spatial nuclear arrangement have been linked to control of gene expression and DNA replication and repair. Genomic techniques based on chromosome conformation… Expand
Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C
- Borbala Mifsud, Filipe Tavares-Cadete, +15 authors C. Osborne
- Biology, Medicine
- Nature Genetics
- 1 June 2015
Transcriptional control in large genomes often requires looping interactions between distal DNA elements, such as enhancers and target promoters. Current chromosome conformation capture techniques do… Expand
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
- B. Javierre, O. Burren, +37 authors Peter Fraser
- Biology, Medicine
- Cell
- 17 November 2016
Summary Long-range interactions between regulatory elements and gene promoters play key roles in transcriptional regulation. The vast majority of interactions are uncharted, constituting a major… Expand
Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins
Mammalian genomes are spatially organized into compartments, topologically associating domains (TADs), and loops to facilitate gene regulation and other chromosomal functions. How compartments, TADs,… Expand
Cell-cycle dynamics of chromosomal organisation at single-cell resolution
- T. Nagano, Yaniv Lubling, +7 authors A. Tanay
- Biology, Medicine
- Nature
- 9 June 2017
Chromosomes in proliferating metazoan cells undergo marked structural metamorphoses every cell cycle, alternating between highly condensed mitotic structures that facilitate chromosome segregation,… Expand
Nuclear organization of the genome and the potential for gene regulation
- Peter Fraser, W. Bickmore
- Biology, Medicine
- Nature
- 23 May 2007
Much work has been published on the cis-regulatory elements that affect gene function locally, as well as on the biochemistry of the transcription factors and chromatin- and histone-modifying… Expand
Long-range chromatin regulatory interactions in vivo
- D. Carter, L. Chakalova, C. Osborne, Y. Dai, Peter Fraser
- Biology, Medicine
- Nature Genetics
- 11 November 2002
Communication between distal chromosomal elements is essential for control of many nuclear processes. For example, genes in higher eukaryotes often require distant enhancer sequences for high-level… Expand
Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus
- Suzana Hadjur, L. M. Williams, +5 authors M. Merkenschlager
- Biology, Medicine
- Nature
- 14 May 2009
Cohesin-mediated sister chromatid cohesion is essential for chromosome segregation and post-replicative DNA repair. In addition, evidence from model organisms and from human genetics suggests that… Expand