Peter Forsyth

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Selecting harmonious colours for traditional window systems can be a difficult and frustrating endeavor. At the root of this problem is the fact that typical window systems do not allow abstract properties of colours to be specified. Instead, they insist that users specify individual colour values exactly. When many colours are used, the value of each(More)
The chemokine GRO-alpha (CXCL1) has been found to mediate the proliferation of glia progenitor cells during neural development. As malignant gliomas are thought to arise from glia progenitors or their differentiated counterparts, astrocytes or oligodendrocytes, we have investigated whether GRO-alpha regulates the tumor characteristics of glioma cells. We(More)
Glioma is the most common malignant primary brain tumor and is associated with poor prognosis. Genetic factors contributing to glioma risk have recently been investigated through genome-wide association studies (GWAS), implicating seven independent glioma risk loci in six chromosomal regions. Here, we performed an in-depth functional analysis of the risk(More)
Malignant astrocytomas are highly invasive neoplasms infiltrating diffusely into regions of normal brain. Migration or invasion of tumor cells into normal tissue is a principal cause of mortality and is thought to be a multi-factorial process, consisting of cell interaction with ECM and adjacent cells, as well as accompanying biochemical processes(More)
Extracellular proteases are crucial regulators of cell function. The family of matrix metalloproteinases (MMPs) has classically been described in the context of extracel-lular matrix (ECM) remodelling, which occurs throughout life in diverse processes that range from tissue mor-phogenesis to wound healing. Recent evidence has implicated MMPs in the(More)
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